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No significant group differences were observed in age (p = 0.150), gender distribution (p = 0.818) and education duration (p = 0.337).；Cognitive asses…
Most studies were retrospective (91.2%, n = 31) and 7 (20.6%) were multicenter.；Twenty-one studies (61.8%) originated from Eastern countries—10 from C…
Consistent with age‐related declines in fitness, VO2peak was significantly greater in middle‐aged adults compared to older adults, p < 0.001, 95% conf…
Its components include pro-inflammatory cytokines such as interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β), IL-6, IL-8, and tumor necrosis fact…
Waist circumference measured in 2011 and 2015 was used to identify longitudinal patterns by K-means clustering, while C-reactive protein levels measur…
Female C57BL/6J mice aged 6 or 18 months at study onset were fed either normal food (NF) or cuprizone (0.2%) mixed into the diet for 5 weeks.；Notably,…
Specifically, European Union countries estimate a 58% rise in dementia cases between 2025 and 2050 [2].；Among dementia types, Alzheimer’s disease is t…
72 名认知未受损老年人单盲随机对照，训练组 30 分钟/天、每周 5 天、共 12 周；双侧毯部与右侧丘脑后辐射的 FA 下降显著小于对照，PAL 情景记忆改善（P=.04）。
InPlp1Tgmice,theDAM1subpopulation,markedbypro-inflammatory cytokines and chemokines including Ccl4/Mip1b, was significantly expanded, comprising appro…
The neuropathological features of AD are extracellular plaques containing aggregated Aβ (amyloid-β), generated through sequential β- and γ-secretase c…
The 10 µM cisplatin caused approximately 70% of IHCs and 71% of OHCs to disappear, with statistically significant loss in both two types of HCs compar…
The union of the five original exports retrieved all 33 final included reports (100%), although no single database was complete.；Overall, two trials (…
We analyzed data from 42,987 participants aged ≥65 y who completed the Japan Gerontological Evaluation Study surveys in 2019 and 2022.；Oral frailty wa…
Work in Drosophila establishes that insulin signaling is allatotropic - it stimulates the production and secretion of JH from the corpora allata.；JH t…
It contained 24 geriatric libraries or pools spanning days 0, 1, 2, 3.5, 5 and 7 after notexin injury, together with eight young libraries at days 1 a…
Sporadic AD, which constitutes approximately 95% of all cases, typically manifests after the age of 65 and is referred to as late-onset AD (LOAD)5.；Cu…
结论：The goal is not to force maximal ubiquitination or autophagy, but to restore the timing and selectivity with which healthy cells detect, contain, a…
The prediction showed an average structural similarity of 70.82% and a prediction accuracy of 69.26%, suggesting a moderate-to-good confidence level i…
The expected amount of furfural formed by C5 hydroxylation relative to 5-methylene-2-furanone (C1 hydroxylation) is 15%.；The only existing data indica…
Four [31–33] cohorts AUC estimates were included in the short follow-up subgroup, with a pooled AUC of 0.71 (95% CI 0.65–0.77).；Eight [31–36] were inc…
To systematically map and evaluate the evidence on whether dental care utilization and specific dental interventions are associated with cognitive fun…
In this cross-sectional study, buccal-lingual cross sections of extracted human premolars and molars obtained from donors aged 16 to 77 y were analyze…
The defining pathological hallmarks of AD are extracellular amyloid plaques formed by amyloid-β (Aβ) deposition and intracellular neurofibrillary tang…
We explored associations of diabetes and grip strength with skeletal outcomes using SHARE v8.0.0 (327 248 participants).；The primary analysis used a c…
The mean age was 84.62 years (SD, 10.80), with 21.0% of participants aged 65 to 74 years, 31.2% aged 75 to 84 years, 36.0% aged 85 to 99 years, and 11…
[Convergent validity of WML volume] BAAD‐derived WML volume (from T1) agreed with the visual ratings from the independent FLAIR images: log WML/TIV co…
DHM increased mean lifespan to 21.78 ± 0.32, 22.45 ± 0.33, and 22.96 ± 0.34 days at 50, 100, and 200 μM, respectively, corresponding to extensions of …
Protein–ligand heteroatom distances of ≤3.5 Å were observed in 8.6% of analyzed frames, while distances of ≤4.0 Å occurred in 57.0% of frames, indicat…
结论：Collectively, the present study demonstrates that pharmacological enhancement of endogenous 2-AG signaling through inhibition of its primary hydrol…
Introduction Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–70% of cases worldwide [1].；The developmen…