数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Frailty is a common geriatric syndrome associated with adverse health outcomes.
方法
Data were obtained from 7075 participants in the China Health and Retirement Longitudinal Study.；Logistic regression, cross-lagged analysis, and network analysis were performed.；Participants with high waist circumference combined with low-high or high-high C-reactive protein showed the greatest frailty risk.
核心结论
Waist circumference measured in 2011 and 2015 was used to identify longitudinal patterns by K-means clustering, while C-reactive protein levels measured in 2011 and 2015 were classified as low-low, low-high, high-low, and high-high (with 2 mg/L as the threshold between low and high).；Frailty was assessed in 2018 and 2020 using the Frailty Index.；Logistic regression, cross-lagged analysis, and network analysis were performed. ‖ 结论：These findings highlight the importance of monitoring long-term changes in central obesity and inflammatory status for early identification of individuals at high risk of frailty.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。
原文题录
- 英文标题：Associations of longitudinal patterns of central obesity and chronic low-grade inflammation with incident frailty in middle-aged and older adults.
- 期刊与标识：Maturitas · PMID 42945651 · DOI 10.1016/j.maturitas.2026.109161**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。