https://longbiosci.com LongBiosci 每日更新生物医药、长寿科技、衰老研究领域最新进展。 zh-CN Thu, 18 Jun 2026 12:00:00 GMT https://longbiosci.com/news/DNA-Methylation-Clock-Epigenetic-Progeria-2026.htmlhttps://longbiosci.com/news/DNA-Methylation-Clock-Epigenetic-Progeria-2026.htmlThu, 18 Jun 2026 12:00:00 GMTNature Genetics重磅研究：首次发现DNA甲基化超甲基化可主动驱动干细胞功能障碍与组织衰退，而非仅仅作为衰老的生物标记物。https://longbiosci.com/news/DNA-Methylation-Clock-Socioeconomic-Mortality-2026.htmlhttps://longbiosci.com/news/DNA-Methylation-Clock-Socioeconomic-Mortality-2026.htmlThu, 18 Jun 2026 12:00:00 GMTAging 2026研究：基于NHANES数据证明GrimAge2可解释52%的高技能蓝领vs白领职业死亡率差异，DunedinPoAm解释28%的种族间差异，为理解社会因素如何转化为生物学衰老提供关键量化证据。https://longbiosci.com/news/DNA-Methylation-Clock-Epigenetic-Progeria-2026.htmlhttps://longbiosci.com/news/DNA-Methylation-Clock-Epigenetic-Progeria-2026.htmlThu, 18 Jun 2026 12:00:00 GMTNature Genetics重磅研究：首次发现DNA甲基化超甲基化可主动驱动干细胞功能障碍与组织衰退，而非仅仅作为衰老的生物标记物。https://longbiosci.com/news/Pragmatism-Preclinical-Aging-Research-NatureAging-2026.htmlhttps://longbiosci.com/news/Pragmatism-Preclinical-Aging-Research-NatureAging-2026.htmlWed, 17 Jun 2026 12:00:00 GMTNature Aging发表Steven N. Austad署名文章，指出当前衰老与长寿临床前研究存在系统性方法论缺陷，呼吁采用更务实的研究设计，提高从实验室到临床的可转化性。https://longbiosci.com/news/Partial-Reprogramming-Funding-NewLimit-435M-RetroBio-2026.htmlhttps://longbiosci.com/news/Partial-Reprogramming-Funding-NewLimit-435M-RetroBio-2026.htmlWed, 17 Jun 2026 12:00:00 GMT2026年抗衰老重编程领域融资加速：NewLimit完成4.35亿美元C轮、计划明年启动人体临床；Retro Biosciences估值达18亿美元。https://longbiosci.com/news/Nucleic-Acid-Mislocalization-Coagul-Aging-Review-2026.htmlhttps://longbiosci.com/news/Nucleic-Acid-Mislocalization-Coagul-Aging-Review-2026.htmlWed, 17 Jun 2026 12:00:00 GMT最新开放获取综述揭示：衰老细胞中错位的DNA/RNA片段激活cGAS-STING等天然免疫受体，驱动慢性炎症和血栓倾向（coagul-aging），提出核酸可作为衰老干预的潜在靶点。https://longbiosci.com/news/In-Vivo-circRNA-Macrophage-MMP9-Bone-Aging-2026.htmlhttps://longbiosci.com/news/In-Vivo-circRNA-Macrophage-MMP9-Bone-Aging-2026.htmlTue, 16 Jun 2026 12:00:00 GMTBioactive Materials 2026年6月发表研究，中国团队开发体内 circRNA 工程化巨噬细胞策略，利用凋亡模拟脂质纳米颗粒（aMMP9-LNP）将巨噬细胞转化为抗 MMP9 抗体生物工厂，在老年小鼠中实现骨骼与软骨回春，打通 mRNA 疗法在骨科退行性疾病中的临床转化路径。https://longbiosci.com/news/PAI-1-Inhibitors-Longevity-2026.htmlhttps://longbiosci.com/news/PAI-1-Inhibitors-Longevity-2026.htmlMon, 15 Jun 2026 12:00:00 GMTPAI-1（纤溶酶原激活物抑制剂-1）是衰老机制研究中的关键分子，与细胞衰老、纤维化和心血管疾病密切相关。https://longbiosci.com/news/LATS1-2-CD38-Endothelial-Senescence-Atherothrombosis-2026.htmlhttps://longbiosci.com/news/LATS1-2-CD38-Endothelial-Senescence-Atherothrombosis-2026.htmlSun, 14 Jun 2026 12:00:00 GMTMD Anderson 揭示内皮细胞 LATS1/2 缺失激活 CD38 驱动血栓形成，为心梗与中风提供新靶点。https://longbiosci.com/news/Retro-Biosciences-1.8B-Valuation-2026.htmlhttps://longbiosci.com/news/Retro-Biosciences-1.8B-Valuation-2026.htmlFri, 12 Jun 2026 12:00:00 GMTRetro Biosciences 宣布新一轮融资初始关闭，估值达18亿美元。RTR242 在15个月内完成从适应症筛选到首次人体给药的跨越。https://longbiosci.com/news/NewLimit-435M-Epigenetic-Reprogramming-2026.htmlhttps://longbiosci.com/news/NewLimit-435M-Epigenetic-Reprogramming-2026.htmlFri, 12 Jun 2026 12:00:00 GMTNewLimit 完成 4.35 亿美元 C 轮融资，计划 2027 年启动表观遗传重编程疗法首次人体临床试验。https://longbiosci.com/news/Human-Lifespan-Data-Quality-Challenge-2026.htmlhttps://longbiosci.com/news/Human-Lifespan-Data-Quality-Challenge-2026.htmlFri, 12 Jun 2026 12:00:00 GMT百岁老人数据质量堪忧，蓝区传说和珍妮·卡尔芒记录可能均非真实，长寿研究领域面临方法论危机。Fight Aging! 2026年6月分析。https://longbiosci.com/news/Time-Restricted-Feeding-Healthspan-NatureAging-2026.htmlhttps://longbiosci.com/news/Time-Restricted-Feeding-Healthspan-NatureAging-2026.htmlFri, 12 Jun 2026 12:00:00 GMT终身限时进食可延长非肥胖小鼠健康寿命，影响存在显著性别差异。Nature Aging 2026年6月发表。https://longbiosci.com/news/IFNAR1-Mitochondria-Parkinson-Dementia-2026.htmlhttps://longbiosci.com/news/IFNAR1-Mitochondria-Parkinson-Dementia-2026.htmlFri, 12 Jun 2026 12:00:00 GMT丹麦团队首次在体阐明IFNAR1在神经元与星形胶质细胞中的缺失如何通过损害线粒体自噬驱动PDD发生。https://longbiosci.com/news/Phosphatidylcholine-Mitochondrial-Aging-Nature-Communications-2026.htmlhttps://longbiosci.com/news/Phosphatidylcholine-Mitochondrial-Aging-Nature-Communications-2026.htmlThu, 11 Jun 2026 12:00:00 GMT德国FLI研究团队在Nature Communications发表研究，揭示磷脂酰胆碱流失是线粒体衰老的关键驱动因素，补充该物质可在两天内恢复线粒体年轻态。https://longbiosci.com/news/Mitochondria-Master-Regulator-Aging-Inflammaging-2026.htmlhttps://longbiosci.com/news/Mitochondria-Master-Regulator-Aging-Inflammaging-2026.htmlWed, 10 Jun 2026 12:00:00 GMT2026年6月开放获取综述提出线粒体功能障碍不仅是衰老的标志之一，更是干细胞耗竭与炎症衰老的 upstream 上游驱动因素，整合生物能量学、氧化还原调控与固有免疫信号，为抗衰老干预提供系统性框架。https://longbiosci.com/news/cGAS-STING-Neuroinflammation-Therapeutic-Target-2026.htmlhttps://longbiosci.com/news/cGAS-STING-Neuroinflammation-Therapeutic-Target-2026.htmlWed, 10 Jun 2026 12:00:00 GMT2026年6月开放获取综述深入解析cGAS-STING信号通路在衰老大脑中的过度激活如何驱动神经炎症与神经退行，并探讨选择性抑制该通路作为神经退行性疾病治疗策略的可行性。https://longbiosci.com/news/Engineered-Gut-Bacteria-LBP-FMT-Clinical-Trial-2026.htmlhttps://longbiosci.com/news/Engineered-Gut-Bacteria-LBP-FMT-Clinical-Trial-2026.htmlWed, 10 Jun 2026 12:00:00 GMT标准化工程菌群在复发性艰难梭菌感染试验中与FMT等效，为规模化肠道疗法奠定基础。https://longbiosci.com/news/Misplaced-Nucleic-Acids-Coagul-Aging-2026.htmlhttps://longbiosci.com/news/Misplaced-Nucleic-Acids-Coagul-Aging-2026.htmlTue, 09 Jun 2026 12:00:00 GMT细胞内错位DNA/RNA片段通过cGAS-STING等受体同时触发炎症和凝血，提出coagul-aging新概念。https://longbiosci.com/news/Time-Restricted-Feeding-Healthspan-Lifespan-NatureAging-2026.htmlhttps://longbiosci.com/news/Time-Restricted-Feeding-Healthspan-Lifespan-NatureAging-2026.htmlTue, 09 Jun 2026 12:00:00 GMT终生小鼠实验证明TRF在不改变热量的情况下延长健康寿命，雄性延寿、雌性改善健康指标，性别差异显著。