https://longbiosci.com LongBiosci 每日更新生物医药、长寿科技、抗衰老领域最新研究进展 zh-CN Thu, 04 Jun 2026 00:00:00 -0000 https://longbiosci.com/logo.jpg https://longbiosci.com https://longbiosci.com/news/FAM162A-Mitochondrial-Longevity-2026.html https://longbiosci.com/news/FAM162A-Mitochondrial-Longevity-2026.html FAM162A是定位于线粒体内膜的一种蛋白，新研究揭示它通过与OPA1互作调节线粒体融合与生物能量代谢，过表达FAM162A可延长果蝇寿命、提升抗热应激能力。 Thu, 04 Jun 2026 00:00:00 -0000 https://longbiosci.com/news/Nasal-EV-Brain-Aging-Reversal-TAMU-2026.html https://longbiosci.com/news/Nasal-EV-Brain-Aging-Reversal-TAMU-2026.html 仅两剂鼻喷型细胞外囊泡，即实现大脑神经炎症消退、线粒体功能恢复、记忆显著改善——效应持续数月。 Wed, 03 Jun 2026 00:00:00 -0000 https://longbiosci.com/news/SynCav1-Gene-Therapy-TDP-43-2026.html https://longbiosci.com/news/SynCav1-Gene-Therapy-TDP-43-2026.html AAV-PHP.eB载体递送SynCav1，系统性注射穿越血脑屏障，在TDP-43蛋白病小鼠模型中逆转神经退行性改变。 Tue, 02 Jun 2026 00:00:00 -0000 https://longbiosci.com/news/HMGB1-Exercise-Cardiovascular-Aging-Current-Research-2026.html https://longbiosci.com/news/HMGB1-Exercise-Cardiovascular-Aging-Current-Research-2026.html 运动调控HMGB1水平，在减少慢性炎症性HMGB1升高与保留组织修复功能之间找到平衡点。 Tue, 02 Jun 2026 00:00:00 -0000 https://longbiosci.com/news/Granzyme-K-Aged-CD8-T-cells-Cognitive-Decline-2026.html https://longbiosci.com/news/Granzyme-K-Aged-CD8-T-cells-Cognitive-Decline-2026.html 老年CD8+ T细胞分泌Granzyme K损害海马体功能，抑制GZMK可逆转认知损伤。 Tue, 02 Jun 2026 00:00:00 -0000 https://longbiosci.com/news/SIRT6-AAV-Chromatin-Rejuvenation-Liver-2026.html https://longbiosci.com/news/SIRT6-AAV-Chromatin-Rejuvenation-Liver-2026.html SIRT6过表达可逆转小鼠肝脏年龄相关的染色质结构变化，恢复年轻态基因表达模式，为表观遗传重编程抗衰老提供新证据。 Mon, 01 Jun 2026 00:00:00 -0000 https://longbiosci.com/news/Gerophysics-Physics-Based-Aging-Models-2026.html https://longbiosci.com/news/Gerophysics-Physics-Based-Aging-Models-2026.html 物理学框架揭示衰老规律：损伤饱和清除模型可统一解释三种经典衰老模式，并区分预防性与清除性干预的不同效果。 Mon, 01 Jun 2026 00:00:00 -0000 https://longbiosci.com/news/Psilocybin-Anti-Aging-Longevity-2026.html https://longbiosci.com/news/Psilocybin-Anti-Aging-Longevity-2026.html 迷幻蘑菇成分裸盖菇素可将人类细胞寿命延长超过50%，老年小鼠生存期延长30%。 Sun, 31 May 2026 00:00:00 -0000 https://longbiosci.com/news/Peripheral-Epigenetic-Aging-Centenarians-2026.html https://longbiosci.com/news/Peripheral-Epigenetic-Aging-Centenarians-2026.html 外周血液表观遗传衰老速度可独立预测认知健康百岁老人生存期，与大脑衰老标志物无关。 Sun, 31 May 2026 00:00:00 -0000 https://longbiosci.com/news/Senolytic-Tooth-Aging-NFATC1-Dental-Pulp-2026.html https://longbiosci.com/news/Senolytic-Tooth-Aging-NFATC1-Dental-Pulp-2026.html 牙髓间充质干细胞中NFATC1丢失驱动牙齿衰老，senolytic药物可清除衰老牙髓细胞并恢复牙齿自我修复能力。 Fri, 29 May 2026 00:00:00 -0000 https://longbiosci.com/news/PM20D1-N-oleoyl-Leucine-Microglia-Alzheimer-2026.html https://longbiosci.com/news/PM20D1-N-oleoyl-Leucine-Microglia-Alzheimer-2026.html PM20D1代谢产物N-油酰基亮氨酸（OLE）诱导小胶质细胞清除β-淀粉样蛋白斑块，减少毒性，改善神经保护与认知功能。 Fri, 29 May 2026 00:00:00 -0000 https://longbiosci.com/news/Blm10-PA200-20S-Proteasome-Alpha-Synuclein-2026.html https://longbiosci.com/news/Blm10-PA200-20S-Proteasome-Alpha-Synuclein-2026.html Blm10/PA200激活的20S蛋白酶体可降解α-突触核蛋白，并绕过传统蛋白酶体抑制，为帕金森病及蛋白稳态干预开辟新方向。 Fri, 29 May 2026 00:00:00 -0000 https://longbiosci.com/news/Astrocyte-Two-Pronged-Brain-Aging-Intervention-2026.html https://longbiosci.com/news/Astrocyte-Two-Pronged-Brain-Aging-Intervention-2026.html 最新开放获取研究综述星形胶质细胞在脑衰老中的两种有害转变，并展示两种干预策略——小分子药物调控炎症、基因疗法促进突触蛋白，均在动物模型中实现认知功能恢复。 Fri, 29 May 2026 00:00:00 -0000 https://longbiosci.com/news/APOE2-DNA-Repair-Neuronal-Aging-2026.html https://longbiosci.com/news/APOE2-DNA-Repair-Neuronal-Aging-2026.html 2026年5月发表在Aging Cell的研究发现，APOE2通过激活DNA修复通路减少神经元衰老，为长寿机制提供神经生物学证据。 Fri, 29 May 2026 00:00:00 -0000 https://longbiosci.com/news/Universal-Transcriptomic-Hallmarks-Mammalian-Aging-Mortality-2026.html https://longbiosci.com/news/Universal-Transcriptomic-Hallmarks-Mammalian-Aging-Mortality-2026.html 哈佛团队整合四大哺乳动物11000+份转录组，构建跨物种衰老与死亡时钟，揭示CDKN1A、LGALS3等通用衰老标志物。 Thu, 28 May 2026 00:00:00 -0000 https://longbiosci.com/news/SAV1-Gene-Therapy-Heart-Regeneration-Clinical-Trial-Nature-2026.html https://longbiosci.com/news/SAV1-Gene-Therapy-Heart-Regeneration-Clinical-Trial-Nature-2026.html SAV1基因疗法通过解除心肌细胞分裂刹车，使衰竭心脏重新长出健康心肌，猪模型射血分数提升14%，已进入人体临床试验。 Thu, 28 May 2026 00:00:00 -0000 https://longbiosci.com/news/CD8-T-cells-GZMK-Cognitive-Decline-Immunity-2026.html https://longbiosci.com/news/CD8-T-cells-GZMK-Cognitive-Decline-Immunity-2026.html 衰老循环CD8+ T细胞通过分泌GZMK驱动认知衰退，抑制GZMK可恢复老年小鼠认知功能。 Thu, 28 May 2026 00:00:00 -0000 https://longbiosci.com/news/Repair-Biotechnologies-REP0004-Atherosclerosis-2026.html https://longbiosci.com/news/Repair-Biotechnologies-REP0004-Atherosclerosis-2026.html 基于mRNA脂质纳米颗粒的药物可直接逆转动脉粥样硬化斑块，有望解决人类最大死因。 Wed, 27 May 2026 00:00:00 -0000 https://longbiosci.com/news/SIRT6-Overexpression-Chromatin-Reversal-Liver-2026.html https://longbiosci.com/news/SIRT6-Overexpression-Chromatin-Reversal-Liver-2026.html SIRT6过表达可逆转老年小鼠肝脏染色质结构变化，首次证明 AAV 介导的 SIRT6 可让染色质可及性\ Tue, 26 May 2026 00:00:00 -0000 https://longbiosci.com/news/Hallmarks-Aging-Paradigms-Scientific-Progress-ARR-2026.html https://longbiosci.com/news/Hallmarks-Aging-Paradigms-Scientific-Progress-ARR-2026.html 从哲学和社会学角度分析Hallmarks of Aging框架如何成为当代衰老研究的主导范式。 Tue, 26 May 2026 00:00:00 -0000