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    <title>LongBiosci - 长寿科技资讯</title>
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    <description>最新生物医药与长寿科技研究资讯</description>
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<item><title>载 microRNA 的细胞外囊泡：衰老中的机制与治疗潜力 - LongBiosci</title><link>https://longbiosci.com/news/microRNA-Loaded-Extracellular-Vesicles-Mechanisms-and-Therapeutic-Potential-Senescence-and-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/microRNA-Loaded-Extracellular-Vesicles-Mechanisms-and-Therapeutic-Potential-Senescence-and-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Cellular senescence is a biological process characterized by stable cell cycle arrest that contributes to tumor suppression and tissue remodeling but can also promote aging-associated dysfun</description></item>
<item><title>居家照护复杂精神健康问题老年客户的员工现实与挑战 - LongBiosci</title><link>https://longbiosci.com/news/are-doing-the-best-can-realities-and-challenges-staff-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/are-doing-the-best-can-realities-and-challenges-staff-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>OBJECTIVES: This qualitative study explored the experiences and perspectives of in-home aged care staff supporting clients living with Complex Mental Health Issues (CMHI), including how thes</description></item>
<item><title>涡旋波刺激：衰老肌肉的新型合成代谢刺激 - LongBiosci</title><link>https://longbiosci.com/news/Vortex-wave-stimulation-A-novel-anabolic-stimulus-for-ageing-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Vortex-wave-stimulation-A-novel-anabolic-stimulus-for-ageing-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>（PubMed 未提供摘要）</description></item>
<item><title>急诊科老年患者照护提供者的体验：质性研究 - LongBiosci</title><link>https://longbiosci.com/news/Understanding-the-experience-healthcare-providers-delivering-care-older-adults-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Understanding-the-experience-healthcare-providers-delivering-care-older-adults-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>BACKGROUND: Knowledge gaps remain regarding the current challenges of delivering care to meet the needs of older adults presenting in the Emergency department (ED). This study aimed to explo</description></item>
<item><title>超声作为全葡萄增值的多功能物理平台：从田间管理到智能放大 - LongBiosci</title><link>https://longbiosci.com/news/Ultrasound-Multifunctional-Physical-Platform-for-Whole-Grape-Valorization-From-Field-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Ultrasound-Multifunctional-Physical-Platform-for-Whole-Grape-Valorization-From-Field-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>The grape and wine industry faces prolonged barrel aging, microbial spoilage, protein haze, chemical additives, and inefficient by-product valorization. These challenges motivate nonthermal </description></item>
<item><title>磷酸三丁酯破坏神经元自噬：细胞与大鼠模型中 TLR4 的可能参与 - LongBiosci</title><link>https://longbiosci.com/news/Tributyl-phosphate-disrupts-neuronal-autophagy-potential-involvement-TLR4-cell-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Tributyl-phosphate-disrupts-neuronal-autophagy-potential-involvement-TLR4-cell-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Tributyl phosphate (TBP), a widely used organophosphate ester, exhibits lipophilic characteristics that enable it to cross the blood-brain barrier. Although its neurotoxicity has been confir</description></item>
<item><title>硫氧还蛋白系统：把「氧化还原」接回衰老的因果链 - LongBiosci</title><link>https://longbiosci.com/news/Thioredoxin-System-Senescence-Ageing-Review-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Thioredoxin-System-Senescence-Ageing-Review-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Ageing Research Reviews 系统综述：Trx-1/Trx-2、TrxR1/R2 与 TXNIP 处在氧化应激、细胞衰老与年龄相关疾病的交汇点</description></item>
<item><title>警觉的隐性劳动：ICU 护士如何识别老年患者病情恶化的现象学研究 - LongBiosci</title><link>https://longbiosci.com/news/The-hidden-work-vigilance-phenomenological-study-how-intensive-care-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-hidden-work-vigilance-phenomenological-study-how-intensive-care-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>PURPOSE: Older adults represent a growing proportion of intensive care unit (ICU) admissions, yet deterioration in this population is often subtle and atypical, requiring heightened nursing </description></item>
<item><title>规律运动与心理教育对肌少症老年人生活质量、抑郁与躯体功能的影响：单盲 RCT - LongBiosci</title><link>https://longbiosci.com/news/The-effects-regular-exercise-and-psychoeducation-quality-life-depression-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-effects-regular-exercise-and-psychoeducation-quality-life-depression-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>BACKGROUND: Sarcopenia is a common geriatric syndrome associated with impaired physical function, depressive symptoms, and reduced quality of life. This trial aimed to compare the effects of</description></item>
<item><title>数字素养的双刃剑：主观与客观数字素养对老年人认知健康的分歧效应 - LongBiosci</title><link>https://longbiosci.com/news/The-double-edged-sword-digital-literacy-divergent-effects-subjective-and-objective-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-double-edged-sword-digital-literacy-divergent-effects-subjective-and-objective-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>AIM: To examine how subjective and objective digital literacy influences cognitive health among older adults. DESIGN: Longitudinal panel study using three waves of nationally representative </description></item>
<item><title>衰老巨噬细胞作为骨骼衰老的中枢枢纽：机制、微生态破坏与系统性后果 - LongBiosci</title><link>https://longbiosci.com/news/The-Senescent-Macrophage-Central-Hub-Skeletal-Aging-Mechanisms-Niche-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-Senescent-Macrophage-Central-Hub-Skeletal-Aging-Mechanisms-Niche-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Bone marrow macrophages (BMMs) coordinate skeletal remodelling, haematopoietic niche function, immune surveillance, and tissue repair. Whether a persistent senescent state in BMMs is a causa</description></item>
<item><title>口腔衰弱预防的需求与未来任务 - LongBiosci</title><link>https://longbiosci.com/news/The-Need-for-Oral-Frailty-Prevention-and-Future-Tasks-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-Need-for-Oral-Frailty-Prevention-and-Future-Tasks-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>The Japanese Kashiwa cohort study followed 2,011 adults aged ≥65 years and found that participants with oral frailty, defined as impairment in at least three of six items and observed in 16%</description></item>
<item><title>神经退行的「隐形杀手」：线粒体功能障碍的机制、通路与治疗策略 - LongBiosci</title><link>https://longbiosci.com/news/The-Invisible-Killer-Neurodegeneration-Mitochondrial-Dysfunction-Neurodegenerative-Disorders-Mechanisms-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-Invisible-Killer-Neurodegeneration-Mitochondrial-Dysfunction-Neurodegenerative-Disorders-Mechanisms-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>29 Collectively, these molecular defects lower oxidative‑phosphorylation efficiency, reduce cellular ATP supply and exacerbate electron leakage that fuels further ROS production.；Post‑mortem</description></item>
<item><title>苏醒的隐秘基因组：LINE-1 逆转座子作为心脏衰老与炎症的新兴调控者 - LongBiosci</title><link>https://longbiosci.com/news/The-Hidden-Genome-Awakens-LINE-1-Retrotransposons-Emerging-Regulators-Cardiac-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-Hidden-Genome-Awakens-LINE-1-Retrotransposons-Emerging-Regulators-Cardiac-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Cardiac aging is a major determinant of cardiovascular morbidity and mortality, characterized by progressive myocardial fibrosis, impaired contractile function, vascular dysfunction, and red</description></item>
<item><title>补充油脂与亮氨酸对母猪养分转运、仔猪肌肉发育与抗氧化活性的影响 - LongBiosci</title><link>https://longbiosci.com/news/The-Effects-Supplementing-Oil-and-Leucine-Nutrient-Transport-Sows-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-Effects-Supplementing-Oil-and-Leucine-Nutrient-Transport-Sows-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>This study investigated the effects of dietary soybean oil and leucine (Leu) supplementation during the peripartum and lactating periods on placental nutrient transport, offspring muscle dev</description></item>
<item><title>加拿大硬斑病登记：设计、基线特征与年龄相关差异 - LongBiosci</title><link>https://longbiosci.com/news/The-Canadian-Morphea-Registry-Design-Baseline-Characteristics-and-Age-Related-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/The-Canadian-Morphea-Registry-Design-Baseline-Characteristics-and-Age-Related-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>BACKGROUND: Morphea is a rare immune-mediated fibrosing skin disorder with heterogeneous clinical manifestations across the lifespan. Existing large cohorts have predominantly originated fro</description></item>
<item><title>双相 I 型障碍端粒长度及其与血清皮质醇水平的关系 - LongBiosci</title><link>https://longbiosci.com/news/Telomere-Length-Bipolar-I-Disorder-and-Its-Relationship-with-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Telomere-Length-Bipolar-I-Disorder-and-Its-Relationship-with-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>（原文未给出可直接抽取的对应表述）</description></item>
<item><title>靶向 RIPK1-NF-κB 交互：阿尔茨海默病坏死性凋亡的新视角 - LongBiosci</title><link>https://longbiosci.com/news/Targeting-RIPK1-NF--B-crosstalk-A-novel-perspective-necroptosis-Alzheimer-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Targeting-RIPK1-NF--B-crosstalk-A-novel-perspective-necroptosis-Alzheimer-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Alzheimer&#x27;s disease (AD) is a progressive neurodegenerative condition characterised by gradual neuronal degradation, resulting in cognitive decline and memory loss. Multiple pathogenic mecha</description></item>
<item><title>TOP2A 一塌，核膜跟着塌：拓扑异构酶成了异染色质的守门人 - LongBiosci</title><link>https://longbiosci.com/news/TOP2A-LMNB1-Heterochromatin-Senescence-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/TOP2A-LMNB1-Heterochromatin-Senescence-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Aging Cell：衰老间充质干细胞中 TOP2A 进行性下降，缺失引发 Lamin B1 丢失、异染色质侵蚀与核膜破裂；过表达 TOP2A 可逆转</description></item>
<item><title>依赖型老年人的颞下颌关节脱位：从识别到维护的框架 - LongBiosci</title><link>https://longbiosci.com/news/TMJ-Dislocation-Dependent-Older-Adults-PA-LTC-A-Recognition-to-Maintenance-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/TMJ-Dislocation-Dependent-Older-Adults-PA-LTC-A-Recognition-to-Maintenance-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>OBJECTIVES: To reframe temporomandibular joint dislocation as a potentially reversible oral-function emergency in post-acute and long-term care (PA/LTC) and propose a recognition-to-maintena</description></item>
<item><title>跌倒之后如何维持自主性：就医与日常生活调整的质性访谈研究 - LongBiosci</title><link>https://longbiosci.com/news/Sustaining-agency-after-fall-navigating-healthcare-and-adjusting-everyday-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Sustaining-agency-after-fall-navigating-healthcare-and-adjusting-everyday-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>These findings suggest that, despite operational challenges, implementing fall prevention strategies in the ED is both feasible and effective [ 18 ].；These findings suggest that difficulties</description></item>
<item><title>年龄相关生物标志物与听力障碍的提示性遗传关联：孟德尔随机化研究 - LongBiosci</title><link>https://longbiosci.com/news/Suggestive-genetic-association-between-age-related-biomarkers-and-hearing-impairment-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Suggestive-genetic-association-between-age-related-biomarkers-and-hearing-impairment-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>OBJECTIVE: Observational studies suggest links between biological aging biomarkers and hearing impairment, but causal inference remains limited. Mendelian Randomization (MR) offers a genetic</description></item>
<item><title>随机失效累积作为指数死亡率与选择性消失的基础 - LongBiosci</title><link>https://longbiosci.com/news/Stochastic-failure-accumulation-foundation-for-exponential-mortality-and-selective-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Stochastic-failure-accumulation-foundation-for-exponential-mortality-and-selective-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>从生物学第一性原理推导出 Gompertz-Makeham 死亡率，并解释&quot;选择性消失&quot;与晚期死亡率平台</description></item>
<item><title>早期阿尔茨海默病夫妻照护需求重要性感知的配偶差异 - LongBiosci</title><link>https://longbiosci.com/news/Spousal-Discrepancy-Perceived-Importance-Care-Needs-Among-Couples-Managing-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Spousal-Discrepancy-Perceived-Importance-Care-Needs-Among-Couples-Managing-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>This study examined discrepancies between persons living with dementia (PLWD) and their spousal caregivers in the perceived importance of PLWD&#x27;s care needs, and how caregivers&#x27; dementia know</description></item>
<item><title>新冠疫情期中国老年人社会参与与认知功能：性别与城乡差异 - LongBiosci</title><link>https://longbiosci.com/news/Social-Engagement-and-Cognitive-Function-Among-Chinese-Older-Adults-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Social-Engagement-and-Cognitive-Function-Among-Chinese-Older-Adults-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>ObjectivesThis study examines the association between reduced social engagement and cognitive function among older adults in China during the COVID-19 pandemic with a focus on gender and urb</description></item>
<item><title>单核测序揭示绝经后人类卵巢中**被产次反向抵消**的年龄相关重塑 - LongBiosci</title><link>https://longbiosci.com/news/Single-nucleus-profiling-reveals-age-associated-remodeling-opposed-parity-the-postmenopausal-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Single-nucleus-profiling-reveals-age-associated-remodeling-opposed-parity-the-postmenopausal-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>绝经后人类卵巢单核图谱：439,011 个核揭示衰老重塑，而产次方向相反</description></item>
<item><title>伴侣同住老年糖尿病患者的性生活与糖化血红蛋白水平 - LongBiosci</title><link>https://longbiosci.com/news/Sexuality-and-Glycosylated-Hemoglobin-Levels-Partnered-Older-Adults-With-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Sexuality-and-Glycosylated-Hemoglobin-Levels-Partnered-Older-Adults-With-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>We examined associations between sexual activity, sexual quality, and glycosylated hemoglobin (HbA1c) levels among partnered older adults with diabetes. Using longitudinal data from the Nati</description></item>
<item><title>性激素调节热量限制的年龄与性别依赖获益：GendAge 减重研究方案 - LongBiosci</title><link>https://longbiosci.com/news/Sex-Hormones-Regulators-the-Age--and-Sex-Dependent-Benefits-Caloric-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Sex-Hormones-Regulators-the-Age--and-Sex-Dependent-Benefits-Caloric-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>With nearly two-thirds of the UK population living with overweight or obesity, there is an urgent necessity for evidence-based public health guidance to promote a healthy weight. Current wei</description></item>
<item><title>芝麻素酚减轻中年小鼠酒精诱导结肠衰老：AhR-Nrf2 轴的可能参与 - LongBiosci</title><link>https://longbiosci.com/news/Sesaminol-attenuates-alcohol-induced-colonic-senescence-middle-aged-mice-potential-involvement-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Sesaminol-attenuates-alcohol-induced-colonic-senescence-middle-aged-mice-potential-involvement-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Taken together, these findings suggest that sesaminol may ameliorate the interconnected microbial, metabolic, epithelial, and redox-related responses to chronic alco- hol exposure, thereby a</description></item>
<item><title>血脂异常与年龄相关性白内障：北印度医院病例对照研究 - LongBiosci</title><link>https://longbiosci.com/news/Serum-Lipid-Abnormalities-and-Age-Related-Cataract-A-Hospital-Based-Case-Control-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Serum-Lipid-Abnormalities-and-Age-Related-Cataract-A-Hospital-Based-Case-Control-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Using two-sample Mendelian randomisation, genetically determined primary open-angle glaucoma and myopic refractive error were significantly associated with cataract risk (POAG: OR 1.04, 95% </description></item>
<item><title>衰老生物标志物预测心衰住院后躯体功能与临床结局：REHAB-HF 的启示 - LongBiosci</title><link>https://longbiosci.com/news/Senescence-Biomarkers-Predict-Physical-Function-and-Clinical-Outcomes-After-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Senescence-Biomarkers-Predict-Physical-Function-and-Clinical-Outcomes-After-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>BACKGROUND: Acute decompensated heart failure (ADHF) is the most common cause of hospitalization in older adults. Cellular senescence, a hallmark of aging biology, has been implicated in hea</description></item>
<item><title>老年结直肠癌手术患者衰老自我感知与术后功能下降：前瞻观察研究 - LongBiosci</title><link>https://longbiosci.com/news/Self-perception-ageing-and-postoperative-functional-decline-older-adults-undergoing-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Self-perception-ageing-and-postoperative-functional-decline-older-adults-undergoing-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>（PubMed 未提供摘要）</description></item>
<item><title>节段相位角预测骨质疏松性骨折患者日常活动能力与肌肉健康：回顾队列 - LongBiosci</title><link>https://longbiosci.com/news/Segmental-phase-angle-predictor-activities-daily-living-and-muscle-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Segmental-phase-angle-predictor-activities-daily-living-and-muscle-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>PURPOSE: This study aimed to determine whether the segmental phase angle is associated with clinical outcomes such as activities of daily living (ADL), muscle strength, and skeletal muscle m</description></item>
<item><title>精神分裂症多靶点治疗：雷帕霉素协调 PI3K-AKT/mTOR 信号与细胞因子网络 - LongBiosci</title><link>https://longbiosci.com/news/Schizophrenia-Multitarget-Therapy-Rapamycin-Coordinates-PI3K-AKT-mTOR-Signaling-with-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Schizophrenia-Multitarget-Therapy-Rapamycin-Coordinates-PI3K-AKT-mTOR-Signaling-with-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>33 A meta-analysis revealed that individuals with acute or chronic schizophrenia-spectrum disorders exhibited persistently elevated IL-6, IL-10, IL-1B, and TNF levels, and IL-4 and IFNG were</description></item>
<item><title>退伍军人痴呆多模式身心运动干预规模化：VA 疗养院 PLIÉ 项目形成性评价 - LongBiosci</title><link>https://longbiosci.com/news/Scaling-multimodal-mind-body-movement-intervention-for-Veterans-with-dementia-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Scaling-multimodal-mind-body-movement-intervention-for-Veterans-with-dementia-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>BackgroundPeople living with Alzheimer&#x27;s disease and related dementias constitute a substantial proportion of residents in U.S. Veterans Health Administration nursing homes (Community Living</description></item>
<item><title>SIRT3 缺失经 SLC25A13 乙酰化触发线粒体功能障碍相关衰老，抑制结直肠癌进展 - LongBiosci</title><link>https://longbiosci.com/news/SIRT3-deficiency-triggers-mitochondrial-dysfunction-associated-senescence-suppress-colorectal-cancer-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/SIRT3-deficiency-triggers-mitochondrial-dysfunction-associated-senescence-suppress-colorectal-cancer-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Mitochondrial dysfunction is frequently well-known to induce mitochondrial dysfunction-associated senescence (MIDAS), a specialized form of cellular senescence marked by a distinct senescent</description></item>
<item><title>阿尔茨海默病中的 SIRT1 信号：线粒体生物发生调控与治疗含义 - LongBiosci</title><link>https://longbiosci.com/news/SIRT1-Signaling-Alzheimer-Disease-Regulation-Mitochondrial-Biogenesis-and-Therapeutic-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/SIRT1-Signaling-Alzheimer-Disease-Regulation-Mitochondrial-Biogenesis-and-Therapeutic-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Alzheimer&#x27;s disease (AD) is one of the leading causes of dementia worldwide. Its pathological features include Aβ deposition, Tau hyperphosphorylation, and impaired neuronal energy metabolis</description></item>
<item><title>视网膜微血管改变与东南亚无痴呆老年人轻度行为损害相关 - LongBiosci</title><link>https://longbiosci.com/news/Retinal-microvasculature-alterations-are-associated-with-mild-behavioral-impairment-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Retinal-microvasculature-alterations-are-associated-with-mild-behavioral-impairment-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Taken together, the findings of this study extend current evidence by highlighting the role of retinal microvascular alterations in vascular processes relevant to neuropsychiatric symptomato</description></item>
<item><title>白藜芦醇经 SIRT1 介导的 NF-κB 抑制调节骨代谢：分子机制与治疗含义 - LongBiosci</title><link>https://longbiosci.com/news/Resveratrol-Modulates-Bone-Metabolism-Through-SIRT1-Mediated-NF--B-Inhibition-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Resveratrol-Modulates-Bone-Metabolism-Through-SIRT1-Mediated-NF--B-Inhibition-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Osteoporosis and associated skeletal pathologies impose a staggering global health burden, disproportionately impacting elderly populations and postmenopausal women. At the root of excessive</description></item>
<item><title>快速进展型阿尔茨海默病：候选机制与诊断挑战 - LongBiosci</title><link>https://longbiosci.com/news/Rapidly-Progressive-Alzheimer-Disease-Candidate-Mechanisms-and-Diagnostic-Challenges-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Rapidly-Progressive-Alzheimer-Disease-Candidate-Mechanisms-and-Diagnostic-Challenges-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>34 While these findings demonstrate distinct neuropathological signatures, the cross-sectional nature of post-mortem data precludes determining whether mitochondrial dysfunction precedes, fo</description></item>
<item><title>载雷帕霉素壳聚糖修饰 PLGA 纳米粒用于湿性 AMD 治疗的在体研究 - LongBiosci</title><link>https://longbiosci.com/news/Rapamycin-loaded-chitosan-functionalized-poly-lactic-co-glycolic-acid-PLGA-nanoparticles-for-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Rapamycin-loaded-chitosan-functionalized-poly-lactic-co-glycolic-acid-PLGA-nanoparticles-for-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Wet age-related macular degeneration (Wet AMD) is a major cause of vision loss and has been linked to abnormal choroidal neovascularization (CNV). Current therapies require frequent intravit</description></item>
<item><title>RICTOR 经甲硫氨酸循环—线粒体自噬轴调控跨物种互作并影响寿命 - LongBiosci</title><link>https://longbiosci.com/news/RICTOR-regulates-interspecies-crosstalk-that-influences-longevity-through-methionine-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/RICTOR-regulates-interspecies-crosstalk-that-influences-longevity-through-methionine-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>In this study, we show that the C. elegans RICT-1 is a part of a gene- diet interaction that maintains adaptive capacity to diets with different B12 content.；Here, we show that the rict-1 mu</description></item>
<item><title>眼科学中的精神医学：提出眼科—精神疾病框架 - LongBiosci</title><link>https://longbiosci.com/news/Psychiatry-ophthalmology-Proposing-the-ophthalmo-psychiatric-disorders-framework-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Psychiatry-ophthalmology-Proposing-the-ophthalmo-psychiatric-disorders-framework-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>We propose the ophthalmo-psychiatric disorders (OPD) framework as an organizing clinical and research model at the interface of vision science and mental health, and to synthesize, with word</description></item>
<item><title>衰老骨骼肌蛋白稳态网络失调：肌少症与肌肉消耗的机制与治疗靶点 - LongBiosci</title><link>https://longbiosci.com/news/Proteostasis-network-dysregulation-aging-skeletal-muscle-Mechanisms-and-therapeutic-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Proteostasis-network-dysregulation-aging-skeletal-muscle-Mechanisms-and-therapeutic-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Aging is a universal biological process signified by a time-dependent decline in physiological activity, driven by molecular and cellular damage, leading to greater susceptibility to disease</description></item>
<item><title>神经退行中的蛋白质质量控制系统：分子伴侣、细胞骨架与 tau 的致病转变 - LongBiosci</title><link>https://longbiosci.com/news/Protein-Quality-Control-Systems-Neurodegeneration-Chaperones-Cytoskeleton-and-the-Pathogenic-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Protein-Quality-Control-Systems-Neurodegeneration-Chaperones-Cytoskeleton-and-the-Pathogenic-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Maintenance of protein homeostasis is essential for neuronal survival, and its disruption is a defining feature of neurodegenerative diseases. Neurons are particularly vulnerable to proteost</description></item>
<item><title>血清白蛋白在老年心血管疾病管理中的预后价值 - LongBiosci</title><link>https://longbiosci.com/news/Prognostic-Value-Serum-Albumin-Elderly-Cardiovascular-Disease-Management-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Prognostic-Value-Serum-Albumin-Elderly-Cardiovascular-Disease-Management-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>These findings suggested that SA levels may provide additional prognostic information in elderly patients with stable CAD [ 45 ].；SA levels were significantly associated with the incidence o</description></item>
<item><title>代谢与减重手术前的衰弱与不良结局：预后证据的系统综述 - LongBiosci</title><link>https://longbiosci.com/news/Preop-erative-Frailty-and-Adverse-Outcomes-after-Metab-olic-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Preop-erative-Frailty-and-Adverse-Outcomes-after-Metab-olic-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Preoperative frailty is increasingly recognized as a predictor of adverse outcomes following metabolic and bariatric surgery (MBS). We systematically reviewed eight retrospective studies wit</description></item>
<item><title>Pot1a 维持间充质干细胞微环境功能以支持造血干细胞 - LongBiosci</title><link>https://longbiosci.com/news/Pot1a-maintains-mesenchymal-stem-cell-niche-function-support-hematopoietic-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Pot1a-maintains-mesenchymal-stem-cell-niche-function-support-hematopoietic-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>Hematopoietic stem cells (HSCs) maintain their function through interactions with niche cells in the bone marrow. We previously demonstrated that protection of telomeres 1a (Pot1a), a shelte</description></item>
<item><title>后生元作为靶向子宫内膜衰老的策略 - LongBiosci</title><link>https://longbiosci.com/news/Postbiotics-Strategy-Target-Endometrial-Aging-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Postbiotics-Strategy-Target-Endometrial-Aging-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>（PubMed 未提供摘要）</description></item>
<item><title>人口老龄化与护理监管：强化老年护理人力的政策策略 - LongBiosci</title><link>https://longbiosci.com/news/Population-aging-and-nursing-regulation-Policy-strategies-strengthen-the-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Population-aging-and-nursing-regulation-Policy-strategies-strengthen-the-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>BACKGROUND: Population aging is increasing demand for nurses prepared to care for older adults. Regulatory frameworks governing nursing education, competence, and workforce standards influen</description></item>
<item><title>帕金森病 iPSC-多巴胺神经元的表型筛选鉴定 FASN-SREBP1 轴为治疗通路 - LongBiosci</title><link>https://longbiosci.com/news/Phenotypic-screening-Parkinson-iPSC-dopamine-neurons-identifies-the-FASN-SREBP1-axis-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Phenotypic-screening-Parkinson-iPSC-dopamine-neurons-identifies-the-FASN-SREBP1-axis-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>4,108 化合物表型筛选锁定 FASN-SREBP1 轴：PD iPSC-多巴胺神经元的靶点发现平台</description></item>
<item><title>卵巢静脉血栓：急症医师面对的少见部位静脉血栓的诊断与处理 - LongBiosci</title><link>https://longbiosci.com/news/Ovarian-Vein-Thrombosis-Diagnosis-and-Management-Unusual-Site-Venous-Thrombosis-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Ovarian-Vein-Thrombosis-Diagnosis-and-Management-Unusual-Site-Venous-Thrombosis-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>（原文未给出可直接抽取的对应表述）</description></item>
<item><title>神经退行疾病新型睡眠分期方法：晚期帕金森病的可行性与可靠性 - LongBiosci</title><link>https://longbiosci.com/news/Novel-sleep-scoring-method-for-neurodegenerative-diseases-feasibility-and-2026.html</link><guid isPermaLink="true">https://longbiosci.com/news/Novel-sleep-scoring-method-for-neurodegenerative-diseases-feasibility-and-2026.html</guid><pubDate>Tue, 03 Nov 2026 00:00:00 +0000</pubDate><dc:creator>LongBiosci 编辑部</dc:creator><description>INTRODUCTION: In neurodegenerative diseases, damage to sleep-wake regulating brain regions alters sleep architecture (e.g., loss of spindles and K-complexes, EEG slowing during wakefulness a</description></item>








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