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      <title><![CDATA[终身限时进食延长健康寿命：小鼠研究揭示性别特异性效应]]></title>
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      <description><![CDATA[终身限时进食可延长非肥胖小鼠健康寿命，影响存在显著性别差异。Nature Aging 2026年6月发表。]]></description>
      <pubDate>Fri, 12 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[IFNAR1 缺失驱动帕金森病痴呆：线粒体与神经能量代谢的细胞特异性病理]]></title>
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      <description><![CDATA[丹麦团队首次在体阐明IFNAR1在神经元与星形胶质细胞中的缺失如何通过损害线粒体自噬驱动PDD发生。]]></description>
      <pubDate>Fri, 12 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[人类能活多久？数据质量困局让答案成谜]]></title>
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      <description><![CDATA[百岁老人数据质量堪忧，蓝区传说和珍妮·卡尔芒记录可能均非真实，长寿研究领域面临方法论危机。Fight Aging! 2026年6月分析。]]></description>
      <pubDate>Fri, 12 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[磷脂酰胆碱流失：细胞衰老的]]></title>
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      <description><![CDATA[德国FLI研究团队在Nature Communications发表研究，揭示磷脂酰胆碱流失是线粒体衰老的关键驱动因素，补充该物质可在两天内恢复线粒体年轻态。]]></description>
      <pubDate>Thu, 11 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[cGAS-STING通路与神经炎症：从感知机制到治疗靶点 - LongBiosci]]></title>
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      <description><![CDATA[2026年6月开放获取综述深入解析cGAS-STING信号通路在衰老大脑中的过度激活如何驱动神经炎症与神经退行，并探讨选择性抑制该通路作为神经退行性疾病治疗策略的可行性。]]></description>
      <pubDate>Wed, 10 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[线粒体：衰老的主调控器，连接能量代谢与慢性炎症 - LongBiosci]]></title>
      <link>https://longbiosci.com/news/Mitochondria-Master-Regulator-Aging-Inflammaging-2026.html</link>
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      <description><![CDATA[2026年6月开放获取综述提出线粒体功能障碍不仅是衰老的标志之一，更是干细胞耗竭与炎症衰老的 upstream 上游驱动因素，整合生物能量学、氧化还原调控与固有免疫信号，为抗衰老干预提供系统性框架。]]></description>
      <pubDate>Wed, 10 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[工程菌群替代粪菌移植：15菌株LBP临床试验证明等效性]]></title>
      <link>https://longbiosci.com/news/Engineered-Gut-Bacteria-LBP-FMT-Clinical-Trial-2026.html</link>
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      <description><![CDATA[标准化工程菌群在复发性艰难梭菌感染试验中与FMT等效，为规模化肠道疗法奠定基础。]]></description>
      <pubDate>Wed, 10 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[限时进食延长健康寿命：终生实验揭示性别差异]]></title>
      <link>https://longbiosci.com/news/Time-Restricted-Feeding-Healthspan-Lifespan-NatureAging-2026.html</link>
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      <description><![CDATA[终生小鼠实验证明TRF在不改变热量的情况下延长健康寿命，雄性延寿、雌性改善健康指标，性别差异显著。]]></description>
      <pubDate>Tue, 09 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[错位核酸触发凝血衰老：Ageing Research Reviews 2026 综述解读]]></title>
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      <description><![CDATA[细胞内错位DNA/RNA片段通过cGAS-STING等受体同时触发炎症和凝血，提出]]></description>
      <pubDate>Tue, 09 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[ProAL50：基于50种循环蛋白的压力负荷评估新方法，优于传统指标]]></title>
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      <description><![CDATA[ProAL50利用50种循环蛋白构建压力负荷评估工具，在UK Biobank和CARDIA研究中均优于传统指标，预测慢性疾病和死亡风险更精准。]]></description>
      <pubDate>Mon, 08 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[运动为何有益？HMGB1：兼具体坏与修复双重角色的\]]></title>
      <link>https://longbiosci.com/news/HMGB1-Exercise-Hormesis-Longevity-2026.html</link>
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      <description><![CDATA[HMGB1作为运动应激hormesis关键介质：急性运动升HMGB1，长期训练降HMGB1，为精准运动处方提供新思路。]]></description>
      <pubDate>Mon, 08 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[GLP-1减肥肌肉流失怎么办？斯坦福团队找到对策]]></title>
      <link>https://longbiosci.com/news/GLP1-Muscle-Preservation-Stanford-PGDHi-2026.html</link>
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      <description><![CDATA[斯坦福大学团队发现，PGDHi抑制剂可恢复GLP-1用药期间的肌肉干细胞再生能力，防止肌力下降。该药已进入临床试验阶段，有望成为GLP-1减肥的标准伴侣用药。]]></description>
      <pubDate>Mon, 08 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[电刺激逆转海鞘衰老：斯坦福团队发现延寿新思路]]></title>
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      <description><![CDATA[斯坦福大学研究团队发现，短暂电脉冲可大幅延长海鞘寿命，通过\]]></description>
      <pubDate>Mon, 08 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[DREAM复合体：连接体细胞突变与寿命的]]></title>
      <link>https://longbiosci.com/news/DREAM-Complex-Somatic-Mutation-Lifespan-NatureAging-2026.html</link>
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      <description><![CDATA[Nature Aging发表重磅研究：DREAM复合体通过调控体细胞突变负担影响寿命和年龄相关疾病。敲除DREAM的小鼠表现出更低的突变负荷和延长的寿命。]]></description>
      <pubDate>Sun, 07 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[蝙蝠长寿启示录：CLSV-6免疫型框架或可重塑人类健康衰老策略]]></title>
      <link>https://longbiosci.com/news/Bat-Longevity-CLSV6-Immunotype-Healthy-Aging-2026.html</link>
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      <description><![CDATA[蝙蝠超长寿命启发CLSV-6免疫型框架，整合六大保守机制，为人类健康衰老提供营养干预路线图。]]></description>
      <pubDate>Sun, 07 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[衰老基因网络揭秘：UK Biobank 57种疾病揭示双重架构]]></title>
      <link>https://longbiosci.com/news/Aging-Gene-Network-Multimorbidity-UK-Biobank-2026.html</link>
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      <description><![CDATA[UK Biobank 57种ARD网络分析揭示衰老基因双重架构：跨系统整合者 vs 疾病簇局部驱动者。]]></description>
      <pubDate>Sun, 07 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[肠道菌群调控谷氨酸恢复老龄卵母细胞质量：Nature Aging 新研究]]></title>
      <link>https://longbiosci.com/news/Gut-Microbiota-Glutamic-Acid-Oocyte-Rejuvenation-2026.html</link>
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      <description><![CDATA[年轻FMT恢复老龄小鼠卵母细胞质量，Bacteroides caecimuris调控的谷氨酸是关键介导因子。]]></description>
      <pubDate>Fri, 05 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[FAM162A：调控线粒体结构与功能的新钥匙，或可延长寿命]]></title>
      <link>https://longbiosci.com/news/FAM162A-Mitochondrial-Longevity-2026.html</link>
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      <description><![CDATA[FAM162A是定位于线粒体内膜的一种蛋白，新研究揭示它通过与OPA1互作调节线粒体融合与生物能量代谢，过表达FAM162A可延长果蝇寿命、提升抗热应激能力。]]></description>
      <pubDate>Thu, 04 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[鼻喷剂逆转大脑衰老：德州农工大学细胞外囊泡研究]]></title>
      <link>https://longbiosci.com/news/Nasal-EV-Brain-Aging-Reversal-TAMU-2026.html</link>
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      <description><![CDATA[仅两剂鼻喷型细胞外囊泡，即实现大脑神经炎症消退、线粒体功能恢复、记忆显著改善——效应持续数月。]]></description>
      <pubDate>Wed, 03 Jun 2026 00:00:00 +0000</pubDate>
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      <title><![CDATA[SynCav1基因疗法：静脉注射即可穿越血脑屏障，靶向TDP-43蛋白病]]></title>
      <link>https://longbiosci.com/news/SynCav1-Gene-Therapy-TDP-43-2026.html</link>
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      <description><![CDATA[AAV-PHP.eB载体递送SynCav1，系统性注射穿越血脑屏障，在TDP-43蛋白病小鼠模型中逆转神经退行性改变。]]></description>
      <pubDate>Tue, 02 Jun 2026 00:00:00 +0000</pubDate>
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