LongBiosci - 长寿科技新闻 https://longbiosci.com 最新抗衰老、长寿科技、生物医药研究资讯 zh-CN 2026-06-02 https://longbiosci.com/logo.jpg LongBiosci https://longbiosci.com <![CDATA[Immunity 2026发表重要研究：老年个体CD8+ T细胞分泌的Granzyme K（GZMK）通过血液循环损害海马体功能，导致认知能力下降；而抑制GZMK可逆转老年小鼠的认知损伤，为阿尔茨海默及年龄相关认知衰退提供全新干预靶点。]]> https://longbiosci.com/news/Granzyme-K-Aged-CD8-T-cells-Cognitive-Decline-2026.html https://longbiosci.com/news/Granzyme-K-Aged-CD8-T-cells-Cognitive-Decline-2026.html Tue, 02 Jun 2026 00:00:00 +0000 <![CDATA[Current Research in Physiology 2026发表综述，系统梳理HMGB1（高迁移率族蛋白B1）在心血管疾病中的作用机制，以及运动如何通过调控HMGB1实现心血管保护效应——既减少慢性炎症性HMGB1升高，又保留其组织修复功能。]]> https://longbiosci.com/news/HMGB1-Exercise-Cardiovascular-Aging-Current-Research-2026.html https://longbiosci.com/news/HMGB1-Exercise-Cardiovascular-Aging-Current-Research-2026.html Tue, 02 Jun 2026 00:00:00 +0000 <![CDATA[物理学研究视角正在进入衰老领域。2026年5月会议综述揭示，损伤饱和清除模型等物理框架可统一解释死亡率指数上升、生理功能线性下降等多种衰老模式，为抗衰老干预效果预测提供数学工具。]]> https://longbiosci.com/news/Gerophysics-Physics-Based-Aging-Models-2026.html https://longbiosci.com/news/Gerophysics-Physics-Based-Aging-Models-2026.html Mon, 01 Jun 2026 00:00:00 +0000 <![CDATA[2026年5月Nature Communications发表研究，SIRT6过表达可在小鼠肝脏中逆转年龄相关的染色质结构变化，将炎症升高、代谢下降的衰老状态恢复至年轻水平，为表观遗传重编程抗衰老提供了新证据。]]> https://longbiosci.com/news/SIRT6-AAV-Chromatin-Rejuvenation-Liver-2026.html https://longbiosci.com/news/SIRT6-AAV-Chromatin-Rejuvenation-Liver-2026.html Mon, 01 Jun 2026 00:00:00 +0000 <![CDATA[阿姆斯特丹自由大学医学中心团队发表最新预印本：外周血液表观遗传衰老速度可独立预测认知健康百岁老人的生存期，且这一预测能力与大脑衰老生物标志物（神经退行性蛋白、Aβ沉积）完全独立，提示外周衰老是决定极端长寿的独立因素。]]> https://longbiosci.com/news/Peripheral-Epigenetic-Aging-Centenarians-2026.html https://longbiosci.com/news/Peripheral-Epigenetic-Aging-Centenarians-2026.html Sun, 31 May 2026 00:00:00 +0000 <![CDATA[埃默里大学研究团队在npj Aging发表重磅临床前研究：迷幻蘑菇活性成分裸盖菇素（psilocin）可将人类皮肤和肺细胞寿命延长超过50%，老年小鼠生存期延长30%，并改善毛色、体能等衰老外观指标。机制研究揭示其通过减少氧化应激、保护端粒和增强DNA修复发挥抗衰老作用。]]> https://longbiosci.com/news/Psilocybin-Anti-Aging-Longevity-2026.html https://longbiosci.com/news/Psilocybin-Anti-Aging-Longevity-2026.html Sun, 31 May 2026 00:00:00 +0000 <![CDATA[2026年5月发表在Aging Cell的研究发现，APOE2基因变体通过激活DNA修复信号通路，显著减少神经元衰老。这为理解APOE2的长寿机制提供了直接神经生物学证据。]]> https://longbiosci.com/news/APOE2-DNA-Repair-Neuronal-Aging-2026.html https://longbiosci.com/news/APOE2-DNA-Repair-Neuronal-Aging-2026.html Fri, 29 May 2026 00:00:00 +0000 <![CDATA[最新开放获取研究综述星形胶质细胞在脑衰老中的两种有害转变，并展示两种干预策略：小分子药物调控炎症反应、基因疗法促进突触蛋白合成——均已在动物模型中实现认知功能恢复。]]> https://longbiosci.com/news/Astrocyte-Two-Pronged-Brain-Aging-Intervention-2026.html https://longbiosci.com/news/Astrocyte-Two-Pronged-Brain-Aging-Intervention-2026.html Fri, 29 May 2026 00:00:00 +0000 <![CDATA[2026年6月发表于Aging Cell的研究发现，Blm10/PA200激活的20S蛋白酶体可有效降解α-突触核蛋白单体和寡聚体，并绕过传统蛋白酶体的抑制，为帕金森病及衰老相关蛋白病开辟新治疗方向。]]> https://longbiosci.com/news/Blm10-PA200-20S-Proteasome-Alpha-Synuclein-2026.html https://longbiosci.com/news/Blm10-PA200-20S-Proteasome-Alpha-Synuclein-2026.html Fri, 29 May 2026 00:00:00 +0000 <![CDATA[Cell Death and Differentiation发表研究：PM20D1酶的代谢产物N-油酰基亮氨酸（OLE）可诱导小胶质细胞更高效清除β-淀粉样蛋白，减少斑块毒性，改善认知，为阿尔茨海默病提供全新小胶质细胞靶向治疗策略。]]> https://longbiosci.com/news/PM20D1-N-oleoyl-Leucine-Microglia-Alzheimer-2026.html https://longbiosci.com/news/PM20D1-N-oleoyl-Leucine-Microglia-Alzheimer-2026.html Fri, 29 May 2026 00:00:00 +0000 <![CDATA[最新研究（Stem Cell Reports, 2026）揭示牙齿老化的分子机制：牙髓间充质干细胞中NFATC1丢失驱动牙齿衰老，而senolytic药物可通过清除衰老牙髓细胞恢复牙齿的自我修复能力，为保存天然牙提供新策略。]]> https://longbiosci.com/news/Senolytic-Tooth-Aging-NFATC1-Dental-Pulp-2026.html https://longbiosci.com/news/Senolytic-Tooth-Aging-NFATC1-Dental-Pulp-2026.html Fri, 29 May 2026 00:00:00 +0000 <![CDATA[Immunity 2026发表重磅研究：衰老循环CD8+ T细胞通过分泌颗粒酶K（GZMK）驱动海马依赖性认知衰退；抑制GZMK可恢复老年小鼠认知功能，为治疗年龄相关认知障碍提供全新靶点。]]> https://longbiosci.com/news/CD8-T-cells-GZMK-Cognitive-Decline-Immunity-2026.html https://longbiosci.com/news/CD8-T-cells-GZMK-Cognitive-Decline-Immunity-2026.html Thu, 28 May 2026 00:00:00 +0000 <![CDATA[Nature News报道：德克萨斯心脏研究所James Martin团队开发的SAV1基因疗法，通过抑制细胞分裂]]> https://longbiosci.com/news/SAV1-Gene-Therapy-Heart-Regeneration-Clinical-Trial-Nature-2026.html https://longbiosci.com/news/SAV1-Gene-Therapy-Heart-Regeneration-Clinical-Trial-Nature-2026.html Thu, 28 May 2026 00:00:00 +0000 <![CDATA[哈佛团队整合四大哺乳动物（鼠、猴、人）11000+份转录组，构建跨物种衰老与死亡时钟，揭示CDKN1A、LGALS3等通用衰老标志物，可预测寿命干预效果、死亡时间和慢性病风险。]]> https://longbiosci.com/news/Universal-Transcriptomic-Hallmarks-Mammalian-Aging-Mortality-2026.html https://longbiosci.com/news/Universal-Transcriptomic-Hallmarks-Mammalian-Aging-Mortality-2026.html Thu, 28 May 2026 00:00:00 +0000 <![CDATA[2026年5月，Repair Biotechnologies 公布其领先候选药 REP-0004 的最新进展。这是一种基于mRNA脂质纳米颗粒的药物，可直接逆转动脉粥样硬化斑块，有望解决人类最大死因——心血管疾病。]]> https://longbiosci.com/news/Repair-Biotechnologies-REP0004-Atherosclerosis-2026.html https://longbiosci.com/news/Repair-Biotechnologies-REP0004-Atherosclerosis-2026.html Wed, 27 May 2026 00:00:00 +0000 <![CDATA[Ageing Research Reviews发表重磅论文，从哲学和社会学角度系统分析]]> https://longbiosci.com/news/Hallmarks-Aging-Paradigms-Scientific-Progress-ARR-2026.html https://longbiosci.com/news/Hallmarks-Aging-Paradigms-Scientific-Progress-ARR-2026.html Tue, 26 May 2026 00:00:00 +0000 <![CDATA[SIRT6（长寿蛋白6）过表达可逆转老年小鼠肝脏细胞中染色质结构的年龄相关变化，恢复炎症下调和代谢功能改善，首次证明 AAV 介导的 SIRT6 可让染色质可及性]]> https://longbiosci.com/news/SIRT6-Overexpression-Chromatin-Reversal-Liver-2026.html https://longbiosci.com/news/SIRT6-Overexpression-Chromatin-Reversal-Liver-2026.html Tue, 26 May 2026 00:00:00 +0000 <![CDATA[低强度脉冲超声（LIPUS）作用于腹部8周，可改善老年小鼠肌肉力量和肌肉质量，其机制与肠道菌群调节相关。该研究发表于Journal of Cachexia, Sarcopenia and Muscle。]]> https://longbiosci.com/news/LIPUS-Gut-Microbiota-Sarcopenia-Aging-2026.html https://longbiosci.com/news/LIPUS-Gut-Microbiota-Sarcopenia-Aging-2026.html Mon, 25 May 2026 00:00:00 +0000 <![CDATA[新加坡1,965名老年人和UK Biobank 43,938名参与者的研究证实：AI衍生的视网膜年龄（RetiAGE）与骨密度降低和骨折风险增加显著相关。视网膜成像或可成为骨质疏松筛查的简便工具。]]> https://longbiosci.com/news/RetiAGE-Retinal-Biological-Age-Predicts-Osteoporosis-2026.html https://longbiosci.com/news/RetiAGE-Retinal-Biological-Age-Predicts-Osteoporosis-2026.html Mon, 25 May 2026 00:00:00 +0000 <![CDATA[韩国KAIST团队在Nature Communications发表研究：发现核糖核酸酶DIS3通过生成tRNA片段（tRH）延缓线虫和人类细胞衰老，揭示了tRNA碎片在长寿干预中的古老而保守的分子机制。]]> https://longbiosci.com/news/DIS3-tRNA-Halves-Aging-NatCommun-2026.html https://longbiosci.com/news/DIS3-tRNA-Halves-Aging-NatCommun-2026.html Sun, 24 May 2026 00:00:00 +0000