https://longbiosci.com/news/ LongBiosci 抗衰老、长寿科技、生物医药领域最新研究资讯 zh-CN Mon, 25 May 2026 00:00:00 GMT https://longbiosci.com/logo.jpg https://longbiosci.com/ https://longbiosci.com/news/LIPUS-Gut-Microbiota-Sarcopenia-Aging-2026.html低强度脉冲超声（LIPUS）作用于腹部8周，可改善老年小鼠肌肉力量和肌肉质量，其机制与肠道菌群调节相关。https://longbiosci.com/news/LIPUS-Gut-Microbiota-Sarcopenia-Aging-2026.htmlMon, 25 May 2026 00:00:00 GMT https://longbiosci.com/news/RetiAGE-Retinal-Biological-Age-Predicts-Osteoporosis-2026.html新加坡1,965名老年人和UK Biobank 43,938名参与者的研究证实：AI衍生的视网膜年龄（RetiAGE）与骨密度降低和骨折风险增加显著相关。视网膜成像或可成为骨质疏松筛查的简便工具。https://longbiosci.com/news/RetiAGE-Retinal-Biological-Age-Predicts-Osteoporosis-2026.htmlMon, 25 May 2026 00:00:00 GMT https://longbiosci.com/news/Naked-Mole-Rat-Skin-ECM-Anti-Aging-2026.html裸鼢鼠寿命长达40年，几乎不出现与年龄相关的组织衰退。最新研究利用拉曼光谱和傅里叶变换红外光谱分析其皮肤细胞外基质分子结构，为抗衰老机制研究提供新线索。https://longbiosci.com/news/Naked-Mole-Rat-Skin-ECM-Anti-Aging-2026.htmlThu, 07 May 2026 00:00:00 GMT https://longbiosci.com/news/Metabolomic-Aging-Clock-Dementia-Risk-UK-Biobank-2026.htmlUK Biobank 22万人研究：代谢年龄超前与APOE ε4叠加，风险激增10.3倍，提示代谢衰老与基因风险独立驱动痴呆。https://longbiosci.com/news/Metabolomic-Aging-Clock-Dementia-Risk-UK-Biobank-2026.htmlWed, 20 May 2026 00:00:00 GMT https://longbiosci.com/news/IGF1R-Inhibitors-Healthspan-Mouse-2026.html两项小分子IGF1R抑制剂（PPP和NVP-ADW742）在C57BL/6小鼠中显示出改善健康寿命的潜力，可减少记忆衰退、降低血压、改善糖耐量，但均存在安全性问题。https://longbiosci.com/news/IGF1R-Inhibitors-Healthspan-Mouse-2026.htmlThu, 07 May 2026 00:00:00 GMT https://longbiosci.com/news/DIS3-tRNA-Halves-Aging-NatCommun-2026.htmlKAIST团队发现核糖核酸酶DIS3通过生成tRNA halves延缓衰老，揭示tRNA碎片是进化保守的长寿机制。https://longbiosci.com/news/DIS3-tRNA-Halves-Aging-NatCommun-2026.htmlSun, 24 May 2026 00:00:00 GMT https://longbiosci.com/news/Peroxisome-Dysfunction-Metabolic-Inflexibility-Longevity-2026.htmlNature Aging 重磅研究揭示过氧化物酶体蛋白转运功能随衰老选择性衰退，是代谢僵硬与寿命缩短的始动级联事件。https://longbiosci.com/news/Peroxisome-Dysfunction-Metabolic-Inflexibility-Longevity-2026.htmlSun, 24 May 2026 00:00:00 GMT https://longbiosci.com/news/Gut-Exosome-Aging-Microbiome-2026.html老年小鼠粪便泌腺体携带促衰老分子，可损害肠道屏障完整性并加速代谢衰退。https://longbiosci.com/news/Gut-Exosome-Aging-Microbiome-2026.htmlFri, 22 May 2026 00:00:00 GMT https://longbiosci.com/news/Cyclarity-UDP003-7KC-Phase1-2026.htmlPhase 1数据证明7KC可安全靶向清除，心血管疾病治疗从管理损伤迈向逆转斑块。https://longbiosci.com/news/Cyclarity-UDP003-7KC-Phase1-2026.htmlFri, 22 May 2026 00:00:00 GMT https://longbiosci.com/news/Serial-Cloning-58-Generations-Lifespan-Nature-2026.html20年、58代、1200只克隆小鼠——日本团队证实：克隆动物寿命正常，性繁殖可纠错表观遗传异常。https://longbiosci.com/news/Serial-Cloning-58-Generations-Lifespan-Nature-2026.htmlSat, 23 May 2026 00:00:00 GMT https://longbiosci.com/news/IDOL-Enzyme-Alzheimers-Target-2026.html大脑IDOL酶是阿尔茨海默病的新型靶点，敲降神经元IDOL可显著减少淀粉样斑块，同时增强神经保护效应。https://longbiosci.com/news/IDOL-Enzyme-Alzheimers-Target-2026.htmlFri, 22 May 2026 00:00:00 GMT https://longbiosci.com/news/KHL-Foundation-Rejuvenation-Cocktail-2026.html抗衰老运动元老 Kenneth Scott 与 Helga Sands 创立医疗旅游项目，提供 klotho + follistatin + sirtuin 1 基因疗法，面向60岁以上人群。https://longbiosci.com/news/KHL-Foundation-Rejuvenation-Cocktail-2026.htmlFri, 22 May 2026 00:00:00 GMT https://longbiosci.com/news/Celastrol-Exercise-Mimetic-Longevity-2026.html雷公藤红素（Celastrol）可模拟运动和PGC-1α过表达对肌肉和线粒体的有益效应，在线虫中延长寿命27.6%。https://longbiosci.com/news/Celastrol-Exercise-Mimetic-Longevity-2026.htmlTue, 12 May 2026 00:00:00 GMT https://longbiosci.com/news/Sleep-Duration-Biological-Aging-Nature-2026.html50万人研究揭示：每天6-8小时睡眠与最慢生物衰老速度相关，睡太多或太少均加速衰老，为睡眠干预抗衰老提供强有力证据。https://longbiosci.com/news/Sleep-Duration-Biological-Aging-Nature-2026.htmlWed, 20 May 2026 00:00:00 GMT https://longbiosci.com/news/ISR-ATF4-Longevity-Fly-PNAS-2026.htmlPNAS 2026年新研究首次在果蝇中验证整合应激反应通路与寿命的关系，发现抑制 ATF4 延长寿命，与线虫结果相反。https://longbiosci.com/news/ISR-ATF4-Longevity-Fly-PNAS-2026.htmlTue, 19 May 2026 00:00:00 GMT https://longbiosci.com/news/Neuroectodermal-Aging-Primate-Longevity-2026.html中山大学与约翰霍普金斯大学合作：神经外胚层来源组织的衰老特征可编码灵长类健康与寿命，为非侵入性长寿评估开辟新路径。https://longbiosci.com/news/Neuroectodermal-Aging-Primate-Longevity-2026.htmlTue, 19 May 2026 00:00:00 GMT https://longbiosci.com/news/Multimodal-Aging-Longevity-Intervention-2026.htmlMIT、哈佛医学院、Buck衰老研究所、斯坦福大学顶级研究团队联合发布重磅预印本：开发多模态器官与单细胞分辨率生物衰老框架，用于系统发现长寿干预手段。https://longbiosci.com/news/Multimodal-Aging-Longevity-Intervention-2026.htmlTue, 19 May 2026 00:00:00 GMT https://longbiosci.com/news/SIRT6-Chromatin-Aging-Reversal-2026.htmlSIRT6过表达可逆转小鼠肝脏染色质衰老，抑制炎症并恢复代谢基因调控至年轻状态。https://longbiosci.com/news/SIRT6-Chromatin-Aging-Reversal-2026.htmlMon, 18 May 2026 00:00:00 GMT https://longbiosci.com/news/Integrator-Depletion-Extends-Lifespan-C-elegans-2026.html最新研究显示，在秀丽隐杆线虫成年期特异性降解Integrator复合体，可显著延长寿命并改善健康跨度。https://longbiosci.com/news/Integrator-Depletion-Extends-Lifespan-C-elegans-2026.htmlWed, 13 May 2026 00:00:00 GMT https://longbiosci.com/news/ECM-Aging-Senescence-Circuit-Nature-Aging-2026.htmlECM老化驱动衰老细胞积累，衰老细胞反过来加剧ECM紊乱。Nature Aging新评述提出自强化回路概念，为抗衰老干预提供新靶点。https://longbiosci.com/news/ECM-Aging-Senescence-Circuit-Nature-Aging-2026.htmlMon, 04 May 2026 00:00:00 GMT