数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Ageing is a well-known, independent risk factor for cardiovascular disease (CVD) (1).
方法
All procedures involving animals were approved by the Norwegian Food Safety Authority under FOTS ID 20208, and were carried out in compliance with national regulations for the care and use of laboratory animals and the ARRIVE 2.0 guidelines (12).；[Animals] Sprague-Dawley rats from ENVIGO were clinically healthy upon inclusion and had not been exposed to any experimental procedures.；Rats that met predefined humane endpoints during the study were excluded (n = 12).；Included animals were euthanized at one of four predefined age points: 3 months [n = 9, mean body weight (BW) 363 g], 9 months (n = 9, mean BW 506 g), 16 months (n = 13, mean BW 634 g), and 24 months (n = 20, mean BW 596 g).
核心结论
The cutoff was set to the mean value + >2 SDs at 9-months, except from LVEF where the threshold was set to 40% to reflect the traditional clinical definition of HF with reduced ejection fraction (HFrEF).；Cutoff for stratification was set at the mean + >2 SD of the 9-month group, except for LVEF, where the cutoff was set at 40% to reflect the traditional clinical definition of heart failure with reduced ejection fraction (HFrEF).；TL, Tibia length; AU, arbitrary units; ns, not significant, * p < 0.05. ‖ 结论：In the preclinical Sprague-Dawley rat model, which displayed a cardiac phenotype resembling human ageing over 2 years, we found no changes in neither leukocyte nor cardiac telomere lengths, suggesting a translational gap vs. humans, where shortening telomere lengths are well-established in ageing.
局限
全文未设独立 limitations 节；结构上为非 RCT 设计，因果推断强度受限。
对本项目的价值
★★☆☆☆ 血管老化提供可影像量化、可短期读取的中间终点，适合做机制到临床的桥接。最大样本量约 51；设计 孟德尔随机化、Meta 分析。
全文来源
PMC JATS 全文（正文 24,041 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Age-related cardiac dysfunction is not associated with shorter telomere length in laboratory rats.
- 期刊与标识：Front Cardiovasc Med · PMID 42947745 · DOI 10.3389/fcvm.2026.1790767**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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