数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
to analyze if healthy fellow eyes (FE) of patients with idiopathic macular hole (IMH) present an aging-like foveal profile.
方法
Foveal characteristics of healthy FE of patients with unilateral IMH are consistent with an aging-like foveal profile.
核心结论
Ophthalmologic examination was performed, including optical coherence tomography (OCT) and OCT-angiography (OCTA).；FAZ area, superficial capillary plexus (SCP) vessel density (VD) and perfusion density (PD), central foveal thickness (CFT), external limiting membrane (ELM), ellipsoid zone (EZ) thickness, and choroidal thickness (ChT) at 5 locations.；Eyes that showed any abnormal findings by OCT were excluded.；The aging-like foveal profile was defined, in accordance with the literature, when the foveal structures exhibited significantly reduced dimensions compared with age-and sex- matched controls, apart from the foveal avascular zone, which is expected to be larger. ‖ 结论：It is plausible to think that this greater physiological deterioration would exacerbate the effect of tangential vitreofoveal traction, thus increasing the risk of idiopathic macular hole.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
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原文题录
- 英文标题：Evidence of an aging-like foveal profile in healthy fellow eyes of patients with idiopathic macular hole.
- 期刊与标识：Graefes Arch Clin Exp Ophthalmol · PMID 42946898 · DOI 10.1007/s00417-026-07537-1**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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