数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Sarcopenia is characterized by a progressive loss of skeletal muscle mass and strength, typically age-related, and is currently recognized as a potentially reversible muscle disease [1].
方法
A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science to identify studies evaluating sarcopenia in patients undergoing surgery for benign or malignant HPB diseases.；Ultimately, 53 studies met the eligibility criteria and were included in the final analysis.；Inclusion and Exclusion Criteria] Eligible studies were original prospective or retrospective cohort studies published in English that evaluated sarcopenia using radiological methods in adult patients undergoing hepatic, pancreatic, or biliary surgery for benign or malignant conditions.；Studies were included if they assessed CT-derived skeletal muscle mass using predefined cut-off thresholds, irrespective of whether additional functional measures were incorporated, since the former are frequently used as a surrogate for sarcopenia diagnosis in surgical literature.
核心结论
Most studies were retrospective (91.2%, n = 31) and 7 (20.6%) were multicenter.；Twenty-one studies (61.8%) originated from Eastern countries—10 from China (29.4%), 8 from Japan (23.5%), one from Korea (2.9%) and one each from Taiwan and Israel—while 13 studies (38.2%) originated from Western countries (Italy n = 4, the Netherlands n = 3, France n = 3, Germany n = 2, Denmark n = 1).；The CV was 10.9% for male cut-offs and 7.6% for female cut-offs, indicating substantial dispersion in the thresholds applied to patients of both sexes, which was somewhat greater for male thresholds. ‖ 结论：Consistent reporting, as outlined in the proposed checklist, is a prerequisite for multicenter validation of thresholds and for establishing the true prognostic value of sarcopenia in patients undergoing HPB surgery.
局限
This approach was considered appropriate for describing methodological heterogeneity in the published literature, but it does not represent a distribution of independent threshold values.；7.6%), suggesting that the heterogeneity observed is not driven by the repeated use of the same cut-offs.；Several limitations of this review warrant consideration.
对本项目的价值
★★☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。最大样本量约 8,158；设计 横断面、回顾性。
全文来源
PMC JATS 全文（正文 32,809 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Heterogeneity in CT-Based Skeletal Muscle Mass Assessment and Sarcopenia Diagnosis Undermines Comparability in Hepatopancreatobiliary Surgery: A Scoping Review.
- 期刊与标识：J Clin Med · PMID 42941371 · DOI 10.3390/jcm15207856**
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