数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Dementia is one of the leading causes of disability and dependency in older adults [1].
方法
Search Strategy] The units of analysis included in this review are empirical articles published in Scopus, PubMed, and Web of Science.；Reference lists of all included studies were manually searched to identify additional eligible records, adding one study through this method.；Five levels were considered: (1) randomized clinical trial or systematic review/meta-analysis of several studies; (2) prospective cohort study; (3) retrospective cohort study, case–control study, or systematic review of several studies; (4) case series or cross-sectional studies; (5) single case study or expert opinions.
核心结论
Specifically, European Union countries estimate a 58% rise in dementia cases between 2025 and 2050 [2].；Among dementia types, Alzheimer’s disease is the most common type, accounting for 60% to 70% of cases [1].；However, some evidence shows similar dementia progression rates between individuals with SCD (≈7%) and without SCD (≈6%) [13]. ‖ 结论：Ultimately, understanding early hemodynamic patterns in SCD may help identify individuals at higher risk for cognitive impairment/dementia.
局限
However, testing these hypotheses requires future research to address key methodological points.；Future studies should (i) adopt longitudinal and well-powered designs to track fNIRS trajectories in SCD; (ii) improve SCD operationalization to ensure diagnostic consistency; (iii) examine the impact of symptom severity on brain function; (iv) consistently include healthy control groups to establish a baseline for brain activity; (v) include representative samples and balance group sample sizes; (vi) implement challenging cognitive tasks during fNIRS recording to better detect group differences; and (vii) report hemodynamic responses alongside task performance scores.；Third, limited literature…
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 46；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 30,762 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Cerebral Hemodynamic Patterns in People with Subjective Cognitive Decline: A Systematic Review Based on Functional Near-Infrared Spectroscopy.
- 期刊与标识：Brain Sci · PMID 42939380 · DOI 10.3390/brainsci16101130**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。