数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Ageing alters the organization and dynamics of the human brain.
方法
Informed consent was obtained from all participants for being included in the CamCAN dataset, which was collected in compliance with the Helsinki Declaration and was approved by the Cambridgeshire 2 Research Ethics Committee (reference: 10/H0308/50; Shafto et al., 2014).；From this dataset, the current study used the 8:40 (minutes:seconds) eyes closed resting-state MEG scan available for 646 participants.；Participants were uniformly distributed across age deciles (range 18–88) with 363 female and 283 male participants.；We analyzed all participants with MEG data and, to ensure that source localization was methodologically consistent, participants were excluded if their structural MRI data were unavailable.
核心结论
Age did not differ between the sexes, but female participants had higher VSTM (t = 3.91, p = 1 × 10-4) and ACE-R (t = 2.68, p = 0.01) scores and male participants had higher adjusted Cattell scores (t = 2.21, p = 0.03).；[Validating age-related changes in multis] The full factorial mean-centred task PLS with six groups (Age [Young, Middle, and Older] × Sex [Male and Female]) revealed two significant LVs that accounted for 98.40% of the covariance between the factorial design and the MSE curves (Fig.；(A) Each significant latent variables (LV), LV1 and LV2, is represented by two plots: (1) a bar plot of the brain scores of each group to the LV ± a 95% confidence interval and (2) a colour plot of the bootstrap ratios [pink = high bootstrap ratio, blue = low bootstrap ratio] for the MSE curves from each region of interest (68 total, 34 in each hemisphere; RH = right hemisphere, LH = left… ‖ 结论：This study replicated and extended previous findings on how multiscale entropy (MSE) changes across the adult lifespan.
局限
Despite the multiple parallel findings regarding the effects of age and sex on brain-derived entropy measures, the inconsistent reporting of the age and sex interaction warrants further study.
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 646。
全文来源
PMC JATS 全文（正文 55,708 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Interactions between age and sex in multiscale entropy and spectral power changes across the lifespan.
- 期刊与标识：Imaging Neurosci (Camb) · PMID 42936422 · DOI 10.1162/IMAG.a.1407**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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