数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
With the acceleration of global population ageing, cognitive impairments and multiple subtypes of dementia have become an increasingly severe public health challenge, among which Alzheimer’s disease (AD) is one of the most common causes.
方法
This cross-sectional study prospectively enrolled 425 inpatients consecutively admitted to the neurology department of a tertiary hospital in southwestern China between October and December 2025.；Notably, all participants were categorized into different cognitive groups based solely on clinical neuropsychological scales; no amyloid/tau-PET or CSF biomarker testing was performed to confirm Alzheimer‘s disease pathological changes.；In this study, cognitive impairment was defined as a MoCA score <26 for participants with >6 years of education, and <24 for those with ≤6 years of education, consistent with Chinese normative data [32].；All scale items underwent cultural adaptation to ensure semantic equivalence; for instance, descriptions within the ‘somatic anxiety’ section were localised to align with common presenting complaints among Chinese patients.
核心结论
Analysis of demographic characteristics revealed no statistically significant difference in sex distribution between the age <65 years and ≥65 years groups (p = 0.944).；Significant differences were observed in cognitive function between the two patient cohorts (p < 0.001), with age-stratified differences also evident in anxiety status (p < 0.001) and depressive status (p < 0.001).；Among detected biomarkers, statistically significant differences were observed in all markers except Aβ1-42 (p = 0.351) between the two patient groups (p < 0.001). ‖ 结论：Future longitudinal, multi-centre studies with formal interaction testing and validation in independent cohorts are warranted to confirm these exploratory observations and to clarify their potential clinical utility.
局限
These findings should be considered exploratory, as formal interaction testing was not performed.；However, the cross-sectional design precludes any inference about temporal ordering.；Therefore, direct comparison of absolute concentrations and diagnostic performance between our study and plasma-based studies should be interpreted with caution.
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 527；设计 前瞻队列、横断面。
全文来源
PMC JATS 全文（正文 34,676 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Age-Stratified Serum Biomarkers for Discriminating Clinically Defined Cognitive Impairment in Neurological Inpatients: A Cross-Sectional Study.
- 期刊与标识：Brain Sci · PMID 42939332 · DOI 10.3390/brainsci16101080**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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