数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Aging alters the brain's inflammatory profile, which may influence vulnerability to neuroinflammatory insults and the effectiveness of neuroprotective interventions.
方法
This study investigated whether prophylactic administration of L-theanine (LT) and aerobic exercise could attenuate behavioral and molecular changes induced by subchronic systemic lipopolysaccharide (LPS) exposure in aged rats.
核心结论
Three- and eighteen-month-old male Wistar rats received LT, exercise, or both prior to repeated LPS administration.；Behavioral assessments included working, recognition, and spatial short-term memory, followed by hippocampal analyses of inflammatory cytokines, the pCREB/CREB ratio, and Aβ₁-₄₂ expression.；Both aging and LPS administration in 3-month-old rats impaired working memory, spatial short-term memory, and motor activity compared to young adult controls.；Unlike young adult animals, subchronic LPS exposure did not impair cognitive performance in aged rats. ‖ 结论：In conclusion, aged rats exhibited relative resistance to LPS-induced cognitive and inflammatory effects but remained susceptible to amyloid-related changes.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
原文题录
- 英文标题：Aging reshapes the response to subchronic LPS: cognitive and neuroinflammatory resilience with selective amyloid vulnerability and reduced responsiveness to L-Theanine and aerobic exercise.
- 期刊与标识：Behav Brain Res · PMID 42946064 · DOI 10.1016/j.bbr.2026.116553**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。