数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
15 The two processes differ in their structural signatures yet both degrade processing efficiency, and whether digital slowing preferentially reflects one over the other has not been directly examined.
方法
Written informed consent was obtained from all participants before enrollment.；[Missing data] Five participants without MMSE scores were excluded.；[Convergent validity of WML volume] To assess the convergent validity of BAAD‐derived WML (log WML/TIV), we examined its association with visual PVH and DSWMH ratings (0–4, Shinohara classification, 21 Japanese Brain Dock Guidelines 2019, 22 ); because volumetric quantification uses T1‐weighted images and visual ratings use independent FLAIR images, agreement reflects cross‐sequence convergent validity.；Time‐ratio features (each item's time divided by the total) were included only in the tree‐based models (XGBoost, residual stacking), since these compositional features induce multicollinearity in linear models.
核心结论
[Convergent validity of WML volume] BAAD‐derived WML volume (from T1) agreed with the visual ratings from the independent FLAIR images: log WML/TIV correlated strongly with PVH grade (Spearman ρ = 0.752; 95% CI, 0.722–0.779) and DSWMH grade (ρ = 0.720; 95% CI, 0.690–0.749), increasing monotonically across grades (Jonckheere–Terpstra and Kruskal–Wallis, P < 0.001); the most severe grades were infrequent, so some post hoc comparisons did not reach significance.；XGBoost gave the largest ΔR (+0.054; 95% CI, +0.010 to +0.095; p = 0.013) and a significant reduction in MAE (p = 0.003). ‖ 结论：We interpreted these findings as a difference in degree rather than a dissociation.
局限
The main limitation is the absence of AD‐specific biomarkers: neither amyloid or tau imaging nor validated blood‐based markers were available.；The magnitude of the residual‐correlation difference should therefore be interpreted with caution.
对本项目的价值
★★★★☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。顶刊证据；最大样本量约 1,163；设计 系统综述、前瞻队列。
全文来源
PMC JATS 全文（正文 29,200 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Digital completion time relates more strongly to Alzheimer's disease-type atrophy than to vascular burden in a community cohort.
- 期刊与标识：Alzheimers Dement (Amst) · PMID 42948203 · DOI 10.1002/dad2.70526**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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