数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
The key question is therefore not only whether diet is associated with cognition, but which dietary dimensions are being captured and whether they relate to cognitive health in similar ways.
方法
Follow-up surveys have subsequently been conducted in 2000, 2002, 2005, 2008 to 2009, 2011 to 2012, 2014, 2017 to 2018, and 2021.；Participants were eligible for the present analysis if they were aged 65 years or older, had complete information required to derive the three dietary indices, had valid cognitive outcome data, and had a valid positive 2021 sampling weight.；Of the 9720 participants in the 2021 CLHLS, 101 were excluded because of incomplete dietary information, and a further 4 were excluded because of missing or invalid sampling weights, leaving 9615 participants in the final analytic sample.；Participants with missing covariate data were retained because these values were subsequently handled using multiple imputation.
核心结论
The mean age was 84.62 years (SD, 10.80), with 21.0% of participants aged 65 to 74 years, 31.2% aged 75 to 84 years, 36.0% aged 85 to 99 years, and 11.8% aged 100 years or older.；Women accounted for 53.7% of the analytic sample, and 69.4% of participants lived in urban areas.；Overall, 42.2% were married and living with a spouse, 38.9% had two or more chronic diseases, and 28.5% had ADL disability. ‖ 结论：In conclusion, cMIND, dietary diversity, and HPDI were all positively associated with global cognitive function in older Chinese adults, with associations also evident for specific cognitive domains.
局限
Age-related heterogeneity was another notable finding of this study.；The contrasting findings across studies suggest that age-related heterogeneity may depend on the dietary exposure, cognitive outcome, study design, and age distribution of the population examined.；Taken together, these considerations suggest that age-related heterogeneity warrants explicit evaluation in diet–cognition research, particularly in cohorts spanning a wide range of later life.
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。队列：CLHLS；最大样本量约 9,720；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 49,199 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Associations of Distinct Dietary Indices with Global and Domain-Specific Cognition and Age-Related Heterogeneity in Older Chinese Adults.
- 期刊与标识：Nutrients · PMID 42942936 · DOI 10.3390/nu18203365**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。