数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Age-related yellowing and mechanical deterioration of teeth are well recognized in clinical dentistry, yet their interrelationship and underlying mechanisms remain incompletely understood.
方法
This study aimed to clarify the associations among dentin color, mechanical properties, and advanced glycation end-product (AGE) accumulation in aging human dentin.
核心结论
In this cross-sectional study, buccal-lingual cross sections of extracted human premolars and molars obtained from donors aged 16 to 77 y were analyzed.；Dentin was subdivided into 4 anatomical regions (outer/inner crown and outer/inner root).；Yellowness (b*) was quantified from optical microscopy images, and Young's modulus was determined using position-resolved nanoindentation.；Pentosidine concentration was quantified by high-performance liquid chromatography as a surrogate marker of AGE accumulation. ‖ 结论：This study demonstrates that dentin yellowness is significantly correlated with increased stiffness in aging human dentin and is more closely associated with stiffness than pentosidine accumulation alone.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。
原文题录
- 英文标题：Yellowness Correlates with Stiffness in Aging Human Dentin.
- 期刊与标识：JDR Clin Trans Res · PMID 42935233 · DOI 10.1177/23800844261492172**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。