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Finally, although their short generation times and lifespans allow quick data collection, short-lived organisms may exhibit a much greater capacity fo…

Ophthalmologic examination was performed, including optical coherence tomography (OCT) and OCT-angiography (OCTA).；FAZ area, superficial capillary ple…

青年（20–30）、老年（55–65）与八旬/九旬老人（>85）三组中，吞噬与 NETosis 未随龄改变，但基线 ROS 升高、IL-8 升高，且 LTR/LINE 反转录转座子与干扰素应答基因同步上调。

Three- and eighteen-month-old male Wistar rats received LT, exercise, or both prior to repeated LPS administration.；Behavioral assessments included wo…

在 D-半乳糖诱导的毛细胞衰老与 C57BL/6J 小鼠增龄模型中，褐藻寡糖降低 SA-β-gal 与 P16/P21、抑制 NF-κB/NLRP3，长期给药降低 ABR 阈值并减少毛细胞与螺旋神经节变性。

At the highest ratios examined, fluorescence quenching reached 55% for curcumin, 72% for α-bromocurcumin, and 90% for α-chlorocurcumin.；Relative to th…

Direct comparison of the α-LA + AMB group against each monotherapy showed a significantly higher PAT than α-LA alone (p < 0.05), but no significant di…

Spectra were searched with the open-search engine PIPI-C [20], which detects multiple co-occurring modifications on individual peptides [19], using th…

For D. nanus (2022), the male extracts displayed the highest protein content (58%), followed by females (50%) and juveniles (38%).；Similarly, D. sanbo…

FTLD-tau preferentially targets frontal and anterior temporal lobes, including the amygdala, contributing to severe neuropsychiatric symptoms.；This st…

To examine the association between incident AWVs and new dementia medication prescriptions.；Data analysis was performed from August 2025 to August 202…

We analyzed 1488 participants from the National Alzheimer's Coordinating Center with autopsy-confirmed neuropathology and at least 2 caregiver-reporte…

We investigated whether altered AQP4 expression contributes to age-related defects in skeletal muscle regeneration and whether AQP4 may represent a ta…

A widely cited systematic review estimated an overall prevalence of 16.7% by combining autopsy and radiological series (14.4% and 22.5%, respectively)…

A cumulative predicted implantation probability above 60% has been proposed as the threshold for further work-up (1).；A meta-analysis found modestly h…

In bloodstream infections caused by P. aeruginosa, carbapenem resistance is an independent predictor of mortality, with a pooled attributable mortalit…

Statistical analysis is by unpaired two-tailed t test. ∗∗∗∗p < 0.0001.；B. fragilis was grown anaerobically in BHI-S (BHI with 0.5% yeast extract and 0…

Mean inpatient GR duration was 33.1 days in the Better@Home group and 37.6 days in the control group (mean difference 4.5 days; 95% CI −1.7 to 10.7; p…

结论：This article aimed to shed light on how AI accelerates the clinical implementation of biological age rather than chronological age in precision med…

Additional sensitivity analyses addressing potential population overlap among studies derived from the Taiwan NHIRD showed that the pooled association…

This study examined whether acyl-CoA synthetase long-chain family member 4 (ACSL4) contributes to BPA-associated ferro-aging-like urothelial injury.；A…

With its advantages of minimal invasiveness, convenience, affordability, and high accessibility, blood-based testing has overcome the limitations of c…

In addition, NF-κB regulates proinflammatory molecules, including CCAAT-binding protein β (C/EBPβ), bromodomain-containing protein 4 (BRD4), lysine me…

Up to 20–30% of PCA presentations were driven by non-AD pathologies, including Lewy body disease, corticobasal degeneration, or prion disease [150,151…

Although its pathophysiology is strongly associated with pancreatic β-cell dysfunction and altered metabolism in the liver, skeletal muscle, and adipo…

Of these almost 95% (n = 3095) completed the baseline assessment.；The cohort is predominantly of white ethnicity (98.9%), 59.9% female, and has a medi…

Here, we identify a dynamic interplay between cellular vulnerability and circuit-level resilience that shapes cognitive outcomes in AD.；Conversely, a …

SP enriched butyrate-producing gut bacteria, including Lachnospiraceae_NK4A136_group, and increased gut and serum butyrate, consistent with enhanced m…

Here, we show that full-body Cass4 deletion in 5xFAD mice increases amyloid-β (Aβ) deposition, neuronal dystrophy, and cognitive deficits.；Since micro…

We investigated the impact of the CDK4/6i palbociclib on mTORC1 signaling in TSC2-null human-derived cells, TSC2-deficient mouse embryonic fibroblasts…