数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
The number of unsuccessful embryo transfers is often used to describe recurrent implantation failure (RIF) in clinical practice.
方法
A systematic review of conventional and modern endometrial receptivity markers likewise found no established predictive value in clinical practice (58).
核心结论
A cumulative predicted implantation probability above 60% has been proposed as the threshold for further work-up (1).;A meta-analysis found modestly higher endometrial CD56-positive cell levels in RIF, with a standardized mean difference of 0.49 and I-squared of 84%. ‖ 结论:Routine NK testing is not recommended for RIF, and the proposed autophagy-immune links remain insufficient to guide treatment.
局限
全文未设独立 limitations 节;结构上为综述/二次研究,因果推断强度受限。
对本项目的价值
★★☆☆☆ 炎症衰老是几乎所有慢性老年病的公共通路,也是最有希望做"抗炎但保留免疫"解耦的靶点。设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文(正文 26,410 字符,已过标题/DOI 逐字归属校验)
原文题录
- 英文标题:Autophagy as a potential link between progesterone responsiveness and endometrial immune function in recurrent implantation failure.
- 期刊与标识:Front Immunol · PMID 42936121 · DOI 10.3389/fimmu.2026.1990439**
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