数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Even so, the magnitude of this association and its specificity across dementia subtypes remain unclear.
方法
Against this background, we performed this meta-analysis to investigate the associations of bipolar disorder (BD) with risks of all-cause dementia and specific dementia subtypes and provide the best available evidence. he updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Page et al., 2020).；When multiple reports were derived from the same underlying database or population, we assessed the degree of overlap based on study period, participant selection, exposure definition, and outcome ascertainment.；In addition, to assess the potential influence of overlapping study populations among studies derived from the Taiwan National Health Insurance Research Database (NHIRD), we conducted additional sensitivity analyses in which only one of the potentially overlapping Taiwanese studies was retained at a time and the remaining Taiwanese studies were excluded from the corresponding analysis.；The studies included a total of 1,536,508 participants, among whom 90,864 cases of all-cause dementia were reported.
核心结论
Additional sensitivity analyses addressing potential population overlap among studies derived from the Taiwan NHIRD showed that the pooled association remained statistically significant regardless of which Taiwanese study was retained, with pooled RRs ranging from 2.40 to 3.08 (all p < 0.001). ‖ 结论：Further high-quality longitudinal studies are needed to clarify the sources of heterogeneity and the factors underlying the association between BD and dementia.
局限
Third, substantial heterogeneity could not be completely resolved.；Formal tests for subgroup differences suggested that study design may contribute to between-study heterogeneity, whereas no statistically significant subgroup differences were detected by sex or age at onset.；Therefore, the findings regarding age at onset should be interpreted with caution.
对本项目的价值
★★★★★ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 536,508；设计 孟德尔随机化、Meta 分析。
全文来源
PMC JATS 全文（正文 43,276 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Bipolar disorder and risk of all-cause and specific dementia: a systematic review and meta-analysis.
- 期刊与标识：Front Aging Neurosci · PMID 42948010 · DOI 10.3389/fnagi.2026.1980508**
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