数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Apathy is disabling in Alzheimer disease (AD) and related dementias, but its progression across neuropathologies remains unclear.
方法
This cohort study examined longitudinal apathy-neuropathology associations.；We analyzed 1488 participants from the National Alzheimer's Coordinating Center with autopsy-confirmed neuropathology and at least 2 caregiver-reported Neuropsychiatric Inventory Questionnaire assessments.
核心结论
We analyzed 1488 participants from the National Alzheimer's Coordinating Center with autopsy-confirmed neuropathology and at least 2 caregiver-reported Neuropsychiatric Inventory Questionnaire assessments.；Generalized linear mixed models tested associations between apathy and AD, Lewy body disease, frontotemporal lobar degeneration (FTLD), hippocampal sclerosis (HS), cerebrovascular disease, and cerebral amyloid angiopathy.；Time was modeled as years to death, including pathology-by-time interactions.；Models were adjusted for age at death, sex, and Neuropsychiatric Inventory Questionnaire total score excluding apathy. ‖ 结论：The elevated burden in FTLD and HS, particularly among males, underscores the importance of stratified approaches to early detection and intervention targeting apathy in AD and related dementias.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
原文题录
- 英文标题：Neuropathological Correlates of Apathy Progression in Alzheimer Disease and Related Dementias: A Longitudinal NACC Cohort Study.
- 期刊与标识：Alzheimer Dis Assoc Disord · PMID 42949266 · DOI 10.1097/WAD.0000000000000754**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。