数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Pseudomonas aeruginosa (P. aeruginosa) is a prominent opportunistic pathogen and a major cause of antimicrobial-resistant infections worldwide.
方法
（全文无独立方法节，正文亦未给出可抽取的实验动作句）
核心结论
In bloodstream infections caused by P. aeruginosa, carbapenem resistance is an independent predictor of mortality, with a pooled attributable mortality of approximately 8–18% and an adjusted odds ratio of approximately 3 (Zhang et al., 2016).；In macrophages, P. aeruginosa induces autophagy through Toll-like receptor 4 (TLR4) and its adaptor TIR-domain-containing adapter-inducing interferon-β (TRIF), whereas activation of the NLRC4–caspase-1 pathway can counteract this response by cleaving TRIF (Jabir et al., 2015).；ATG16L1 deficiency enhances caspase-1 activation and LPS-induced maturation and release of IL-1β through a TIR-domain-containing adapter-inducing interferon-β (TRIF)-dependent mechanism, indicating that an intact autophagy apparatus exerts negative control over inflammasome signaling (Saitoh et al., 2008). ‖ 结论：Rather, it represents a dynamic competition between the host and the pathogen across multiple checkpoints of the autophagy–lysosome pathway.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
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全文来源
PMC JATS 全文（正文 69,651 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Autophagy in Pseudomonas aeruginosa infection: host defense, bacterial countermeasures, and therapeutic targeting.
- 期刊与标识：Front Microbiol · PMID 42935687 · DOI 10.3389/fmicb.2026.1976209**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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