数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
As a central energy status sensor in eukaryotic cells, AMPK orchestrates metabolic homeostasis through its heterotrimeric complex comprising catalytic α-subunits, scaffolding β-subunits and regulatory γ-subunits.1 The kinase derives its name from its allosteric activation by AMP binding, which triggers conformation changes that expose the Thr172 phosphorylation site in the α-subunit activation loop, thereby…
方法
When these transgenic mice were fed a high-fat diet, they showed protection against insulin resistance and excessive triglyceride accumulation in skeletal muscles.；Collectively, the body of evidence presented in this review enables the standardized definition of AMPK-related diseases along three hierarchically validated, complementary dimensions: causal verification, interventional reversal, and clinical correlation.
核心结论
Introduction As a central energy status sensor in eukaryotic cells, AMPK orchestrates metabolic homeostasis through its heterotrimeric complex comprising catalytic α-subunits, scaffolding β-subunits and regulatory γ-subunits.1 The kinase derives its name from its allosteric activation by AMP binding, which triggers conformation changes that expose the Thr172 phosphorylation site in the α-subunit activation loop, thereby enabling full kinase activity.；Subsequent studies have confirmed and expanded the canonical activation mechanism of AMPK that occurs through sensing of the cellular ATP:AMP/ADP ratio, with increased AMP levels serving as a primary signal of energy depletion.2 Meanwhile, an expanding repertoire of noncanonical activation mechanisms has been revealed, such as calcium-dependent signaling via Ca2+/calmodulin-dependent protein kinase kinase-beta (CaMKK2/β), lysosomal damage… ‖ 结论：These efforts will be pivotal in translating AMPK research into clinically effective treatments for metabolic, cardiovascular, neurodegenerative and oncological diseases.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★★★ 营养感知与自噬轴决定"干预窗口 + 剂量方案"，是组合疗法的时间锚。顶刊证据；命中核心 mTOR/AMPK；队列：TCGA。
全文来源
PMC JATS 全文（正文 216,162 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：The AMPK signaling pathway in cell metabolism and human diseases.
- 期刊与标识：Signal Transduct Target Ther · PMID 42934234 · DOI 10.1038/s41392-026-02790-6**
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