数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
The Brains for Dementia Research (BDR) project was established to provide high quality, neuropathologically characterized post-mortem brain tissue from a cohort of participants longitudinally assessed for outcomes that are relevant for research in relation to dementia.
方法
A total of 513 publications utilizing BDR have generated since 2009 to‐date.
核心结论
Of these almost 95% (n = 3095) completed the baseline assessment.；The cohort is predominantly of white ethnicity (98.9%), 59.9% female, and has a median of 13 years of education.；1 As of July 2026; 1559 (50% of baseline assessments) participants have died with 1355 brains (86.9%) successfully donated for research purposes.
局限
全文未设独立 limitations 节；结构上为非 RCT 设计，因果推断强度受限。
对本项目的价值
★★★★☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。顶刊证据；队列：ROSMAP、BLSA。
全文来源
PMC JATS 全文（正文 39,816 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Brains for dementia research at 18: Commitment to impact the value of human post-mortem tissue.
- 期刊与标识：Alzheimers Dement · PMID 42934834 · DOI 10.1002/alz.71956**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。