数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Visual dysfunctions were observed among Alzheimer's disease (AD) patients, including posterior cortical degeneration, retinal abnormalities, or coexisting ocular disease.
方法
The brain-versus-eye distinction used in this review was intended as a simplified organizational framework rather than a formal disease taxonomy.；In practice, these mechanisms could overlap, and the conditions discussed in this review, including PCA, hereditary cerebral amyloid angiopathy, glaucoma, AMD, and retinal degeneration, were clinically and pathologically distinct [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23].；In this review, “brain blindness” and “eye blindness” were used only as conceptual labels for central and peripheral sources of visual dysfunction.
核心结论
Up to 20–30% of PCA presentations were driven by non-AD pathologies, including Lewy body disease, corticobasal degeneration, or prion disease [150,151]. ‖ 结论：These data could reflect the pleiotropy, shared susceptibility mechanisms, or related cellular processes.
局限
However, the diagnostic utility of genetics in visual-variant AD remained to be confounded by biological and methodological complexities, including etiological heterogeneity, vascular versus amyloid specificity, or shared pathophysiology with glaucoma.；Future studies should be conducted on larger, prospectively recruited cohorts with standardized clinical criteria, longitudinal tracking, and biomarker-supported etiological classification [151,152].；However, visual disturbances should be considered as a potential, rather than definitive, predictor of AD onset because current evidence showed that early visual involvement remained inconclusive.
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。命中核心 线粒体；队列：Rotterdam Study；设计 横断面。
全文来源
PMC JATS 全文（正文 49,283 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Brain Blindness Versus Eye Blindness: Genetic and Molecular Connections Between Alzheimer's Disease and Visual Impairment.
- 期刊与标识：Curr Issues Mol Biol · PMID 42939619 · DOI 10.3390/cimb48101081**
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