数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Aging is associated with reductions in measures of magnetic resonance imaging (MRI) morphometry across the adult lifespan, 1 , 2 , 3 , 4 including cortical thickness.
方法
Study procedures were approved by The Ohio State University Institutional Review Board, and written informed consent was obtained from all participants.；Of the 18 participants who were excluded for invalid VO2peak, 2 were young adults, 4 were middle‐aged adults, and 12 were older adults.；26 Participants were excluded from analysis if the Euler number was less than 2 standard deviations below the sample's mean (< −35).
核心结论
Consistent with age‐related declines in fitness, VO2peak was significantly greater in middle‐aged adults compared to older adults, p < 0.001, 95% confidence interval (CI) = [4.38, 10.08], and in young adults compared to older adults, p < 0.001, 95% CI = [6.51, 12.54].；All plots shown have a significant Age × VO2peak interaction of q < 0.05 or marginally significant interaction of q < 0.1.；All plots are thresholded to only show significant relationships of p < 0.05. ‖ 结论：These findings suggest that nonlinear modeling may capture important variation in the relationship between cardiorespiratory fitness and cortical thickness across the adult lifespan.
局限
Future studies should investigate nonlinear relationships with cognition to further understand the mechanisms driving this relationship.；Our aim was to establish a methodological foundation for applying nonlinear modeling in this relationship, thereby providing a basis for future studies to refine and extend these findings.；To further extend these findings, it would be important for future studies with larger samples to implement a whole‐brain analysis approach—for example, using all ROIs from a whole‐brain parcellation—or utilize GAMs at the vertex level.
对本项目的价值
★★★★★ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。顶刊证据；最大样本量约 159；设计 系统综述。
全文来源
PMC JATS 全文（正文 26,930 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Differential relationships between cardiorespiratory fitness and cortical thickness across the adult lifespan: A generalized additive model approach.
- 期刊与标识：Alzheimers Dement (N Y) · PMID 42936859 · DOI 10.1002/trc2.70237**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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