数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–70% of cases worldwide [1].
方法
TG11-77 remains a preclinical candidate; no publicly reported human trial was identified in this review.
核心结论
Introduction Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–70% of cases worldwide [1].；The development and progression of AD involve multiple interacting pathological processes, including amyloid-β (Aβ) deposition, tau abnormalities, synaptic injury, and persistent neuroimmune alterations [1,4].；Search terms included combinations of “PGE2,” “PTGER2” or “EP2,” “PTGER4” or “EP4,” “Alzheimer’s disease,” “amyloid-β,” “microglia,” “ageing,” “agonist,” “antagonist,” “pharmacokinetics,” and “clinical trial.” The reference lists of relevant articles were also screened. ‖ 结论：For EP4, it is whether production- and clearance-related actions can be separated sufficiently to define a useful intervention.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。命中核心 线粒体；最大样本量约 443；设计 横断面、多组学。
全文来源
PMC JATS 全文（正文 54,714 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：EP2 and EP4 in Alzheimer's Disease: Cell-Dependent Signalling and Implications for Selective Targeting.
- 期刊与标识：Int J Mol Sci · PMID 42941959 · DOI 10.3390/ijms27209190**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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