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共 2198 篇，本页第 1141–1170 篇
When comparing the expression levels of individual key genes, we observed 6-fold higher expression of SEC61A1, a core translocon component; a 56-fold …
Serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone and estradiol (E2) were measured; antral follicle count (A…
Of note, the improvement rate was between 15% and 30% in Patient 9 during the levodopa challenge test, whereas all other patients in this cohort achie…
结论：Our findings demonstrate that the CKMS model effectively recapitulates a clinically relevant cardio–renal–metabolic state, characterized by profoun…
A global systematic review and meta-analysis published in 2014 estimated that, among individuals aged 45–85 years, the prevalence of early AMD, late A…
The current analyses included 7398 participants from the US Health and Retirement Study (HRS, mean age of 68.7 years, SD 11.0; 41% male) as the develo…
In addition to 5mC, genome-wide profiling of postmortem human brain tissue has identified differentially hydroxymethylated regions associated with amy…
The analytic sample included 442 cognitively healthy adults (mean age = 51.2 years, SD = 5.5; 50.7% women; mean education = 17.2 years, SD = 3.6).；[Re…
Although its anti-tumor and anti-inflammatory effects have been extensively investigated, its potential role in transplant immunology remains unexplor…
HPLC Method Validation] A reversed phase HPLC method was developed for trans-resveratrol (Inertsil ODS-3 column; acetonitrile/0.2% formic acid gradien…
During weeks 1–12, the body weight of the HFD groups was significantly higher than that of the DC group (p < 0.05 or p < 0.01), indicating a marked in…
Understanding the mechanisms by which exercise activates autophagy and elicits metabolic benefits in the liver will provide important insights into th…
A total of 2,969 participants were included in the present study, with a mean age of 66.61 years; 1,495 (51%) were men and 1,474 (49%) were women.；In …
An immunohistochemical study of the lungs of mice of different ages was performed.；The results showed that with age, there is a progressive decrease i…
新登记于 2026-10-27 的 NCT07898839：15 人、Phase 2，用 N-乙酰半胱氨酸、α-硫辛酸、烟酰胺核糖与二甲双胍缓释片组合加研究膳食，检验双硫死亡在胆汁疾病中的作用。
D-半乳糖诱导衰老大鼠接受健康供体粪菌移植后，水迷宫成绩改善，心脏、海马与结肠的组织损伤同步减轻；预先用抗生素清场反而削弱了效果。
Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were reported.；Of these, 67.1% were classified as low HFRS, 31.5% as intermediate HFRS…
Mean ± SD age was 77.1 ± 5.5 years (33% female), with a mean of 2.6 ± 2.0 comorbidities per participant in this highly educated cohort.；Twelve (66.7%)…
2,006 名 ≥65 岁急性老年医学科住院患者，6 个月死亡率 22%；CFS 每增加 1 分死亡风险升 50%，且衰弱越重、加权疾病负担的预后贡献被削弱（交互 p=0.011）。
The pooled random-effects estimate showed no evidence of a treatment effect (Hedges’ g = 0.014, 95% CI: −0.061 to 0.088; p = 0.515), with tau2 = 0 and…
结论：Thus, senescent cells are characterized by the activation of specific tumor suppressor markers, including p53/p21CIP1 and p16INK4a/Rb, which inhibi…
Model Establishment For dietary intervention, the Ganoderma lucidum sporoderm-broken spore powder (GLSP) diet was prepared by uniformly mixing 4 g/kg …
The first principal component accounted for 26.86% of the total expression variance, whereas the second principal component accounted for 7.71%.；SLC19…
Solid arrows indicate significant associations (P < 0.05); dashed arrows, non-significant. ‖ 结论：The present study demonstrated that regular ginseng in…
(n = 3 independent biological replicates) *p < 0.05; p < 0.01; *p < 0.001 (Rb1, ginsenoside Rb1; Young, EnSCs in the young female group; Aging, EnSCs …
A DHEA-induced murine PCOS model was generated for in vivo experiments.；Serum hormonal profiles and insulin sensitivity were assessed.；Ovarian histomo…
Statistical data are presented as the mean ± SD (P < 0.01, P < 0.0001).；Statistical data are presented as the mean ± SD (*P < 0.05, P < 0.01, *P < 0.0…
The evidence base remained markedly uneven: sixteen studies (61.5%) investigated MS/EAE, seven (26.9%) investigated PD, two (7.7%) addressed AD-relate…
Quantitative analysis confirmed that argpyrimidine-positive areas were higher in the HFCS group than in the control group (mean score: 12.1% vs.；Altho…
Suppression of clearance of toxic waste following deletion of AQP4 is further supported by the slowing down of CSF influx by almost 70% [1]. ‖ 结论：Thes…