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About 50% of Long COVID patients are generally believed to meet the diagnostic criteria for ME/CFS, with high degrees of overlap [1,2].；At only 2% of …

Bacterial β-glucuronidases can deconjugate estrogen glucuronides in the intestine, facilitating reabsorption and potentially influencing systemic estr…

ROS, mitochondrial damage, LPS, and other microbial signals can activate NLRP3 inflammasomes, caspase-1, gasdermin D, and release of IL-1 β and IL-18 …

Its core pathological features include amyloid-β(Aβ) deposition, abnormal aggregation of Tau protein, and chronic neuroinflammation, which imposes a h…

Using all available proxies, higher genetically predicted anti-H. pylori IgG seropositivity was associated with lower risk of Alzheimer’s disease (OR …

Frailty was assessed at consultation using the HCT-FS (fit, prefrail, frail).；OS was estimated by Kaplan-Meier, competing-risks methods by cumulative …

结论：In conclusion, HDL functional properties, specifically their capacity to remove excess cholesterol from neurons and to protect brain microvascular …

Because hemocytes are in contact with the hemolymph throughout life, they register the nutritional state of the organism through conserved nutrient-se…

Experimental models have shown that recurrent HSV-1 infection and reactivation can induce several AD-associated pathological features, including amylo…

Age (F = 13.42, p < 0.001), sex (χ2 = 20.79, p < 0.001), and APOE ε4 carrier status (χ2 = 23.61, p < 0.001) all differed significantly across subtypes…

In AD-F mice, DHA and NR treatment also trended toward improved memory compared to AD fed chow, but the difference in latency was not significant (p =…

The drug concentrations and conditions that gave more senescence induction with reduced cell lethality were chosen: 0.05 μM doxorubicin (DR or DoxoR),…

This Review examines how canonical histone modifications and emerging metabolite-derived acylations regulate inflammatory and stress-responsive progra…

Specifically, each 1-SD increase in genetically predicted ESR1 expression was causally associated with a 1.26-SD reduction in PhenoAA (β =−1.26; 95% C…

This ecological study examined country-level associations be-tween average household size and modelled neurological disease incidence estimates.；Count…

The proteostasis network is a fundamental functional unit in biology that is essential for cellular health and has direct relevance to many diseases o…

（原文未设独立引言节）

At 80% power and a two-sided α of 0.05, the median minimum detectable effect across expressed genes was an absolute log2 fold change of 0.465, corresp…

Beyond their baseline anti-inflammatory efficacy, HDACis possess significant therapeutic value in oncology by preventing chimeric antigen receptor T-c…

Block-based statistical analysis of total MM-PBSA energies revealed no significant difference between SIRT1–4TQ and SIRT1–IA (p = 0.260).；In contrast,…

In addition to amyloid-β and tau pathology, the disease is shaped by inflammation, vascular injury, aging biology, metabolic dysfunction, and host-mic…

(D) Analysis of the percentage of the population that was labeled showed that CLD delivered antibody into approximately 65% of the population that was…

Pathophysiologically, AD was traditionally defined as a continuum of neurodegenerative processes driven by the accumulation of amyloid-β (Aβ) plaques …

心脏富集的小非编码 RNA piR-4913 在衰老心脏 I/R 后显著上调，缺血后处理可抑制它；沉默 piR-4913 缩小梗死面积、提升 ATP 并降低氧化应激，机制落在 Drp1 Thr604 的 O-GlcNAc 修饰。

Brain lipid deposition, plasma and brain TC, TG and NEFA levels, and expressions of BACE1, Aβ, p-Tau, ZO-1, occludin, AMPK/p-AMPK, SREBP1, ACC, ATGL, …

Cox proportional hazards regression showed no significant main effect of sex on survival (hazard ratio (HR) = 0.43, p = 0.25). ‖ 结论：Together, these fi…

结论：In conclusion, these findings identify miRNAs in L1CAM-enriched EVs as candidates for further investigation as minimally invasive markers in cognit…

In osteoblastic and pre-osteoblastic cells, LF reduces apoptosis induced by stress conditions via Wnt5a-dependent activation of cAMP/PKA signaling and…

Introduction Laminins are heterotrimeric glycoproteins assembled from five α chains (α1–α5), three β chains (β1–β3), and three γ chains (γ1–γ3).；The t…

The studies were conducted primarily in the United States (n = 9, 36%) (Agbavor and Liang, 2022; Guan et al., 2025; Huang et al., 2025; Kearney et al.…