数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Poor social connection and ageing-related biological processes are recognised contributors to Alzheimer's disease and related dementias.
方法
Analyses included Pearson and Spearman correlations, par-tial correlations, principal component analysis, and multivariable linear regression.
核心结论
This ecological study examined country-level associations be-tween average household size and modelled neurological disease incidence estimates.；Country- and territory-level data from up to 204 settings were analysed.；Average household size was the primary exposure, and model-derived, age-standardised incidence-rate estimates for Alzheimer's disease and other dementias were the primary outcome.；Par-kinson's disease, motor neuron disease, multiple sclerosis, idiopathic epilepsy, headache dis-orders, and total neurological disorders were examined as comparative secondary outcomes. ‖ 结论：Smaller average household size was associated with higher modelled incidence estimates for dementia and selected neurodegenerative diseases at the country level.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
原文题录
- 英文标题：Structural Social Connection, Biological Ageing, and Neurodegenerative Disease Burden: A Global Ecological Analysis of Household Size and Modelled Dementia Incidence Estimates.
- 期刊与标识：Neurodegener Dis · PMID 42945427 · DOI 10.1159/ndd/aduag008**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。