数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Alzheimer’s disease (AD) is a multifactorial, progressive neurodegenerative disorder characterized by memory loss, cognitive dysfunction, and a decline in problem-solving and decision-making abilities.
方法
Aflatoxin B1 (AFB1), a well-established toxic and carcinogenic compound, was included as a positive control for the toxicity prediction workflow.；This analysis was performed solely to assess the ability of the docking workflow to identify a known SIRT1 ligand binding region and was not used for direct comparison with IA or the reference activator 4TQ.；A total of 51 snapshots were included in the exported MM-PBSA output for each protein–ligand complex.；Entropic contributions were not reported in the exported output files and were therefore not included in the present analysis.
核心结论
Block-based statistical analysis of total MM-PBSA energies revealed no significant difference between SIRT1–4TQ and SIRT1–IA (p = 0.260).；In contrast, significant differences were observed between SIRT3–BBI and SIRT3–IA and between SIRT6–8L9 and SIRT6–IA (p < 0.001 for both comparisons).；Quantitative analysis showed that 75.3% of the analyzed cells were NeuN positive, and 69.5% were synaptophysin positive. ‖ 结论：In conclusion, the present findings indicate that IA treatment is associated with changes in insulin-signaling-related proteins, sirtuin expression, inflammatory and oxidative-stress markers, and PPARα in an Aβ1–42-induced cellular AD model.
局限
IA showed predicted H-HT and DILI probabilities of 0.729 and 0.766, respectively, indicating that possible hepatic toxicity should be considered during further development.
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。命中核心 干细胞。
全文来源
PMC JATS 全文（正文 62,353 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Incensole Acetate Regulates the Sirtuin-Insulin Signaling Axis in an Experimental Alzheimer's Disease Model.
- 期刊与标识：Pharmaceuticals (Basel) · PMID 42943270 · DOI 10.3390/ph19101573**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
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