数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Human studies suggest that menopause and estrogen deficiency may be associated with alterations in gut microbial composition and function; however, the direction, magnitude, and reproducibility of these changes remain incompletely defined [7,8].
方法
The review primarily included studies published between January 2010 and April 2026.；Representative search terms included combinations of “menopause”, “postmenopause”, “gut microbiome”, “gut microbiota”, “estrobolome”, “estrogen metabolism”, “β-glucuronidase”, “short-chain fatty acids”, “trimethylamine N-oxide”, “bile acids”, “lipopolysaccharide”, “gut–brain axis”, “gut–muscle axis”, “metabolic syndrome”, “cardiovascular disease”, “metabolic dysfunction-associated steatotic liver disease”, “sarcopenia”, “precision nutrition”, “probiotics”, “synbiotics”, “phytoestrogens”, “hormone replacement therapy”, “metagenomics”, “metabolomics”, and “machine learning”.；Additional relevant publications were identified by manual screening of the reference lists of included studies and relevant reviews.；Eligible publications included randomized controlled trials, prospective and retrospective cohort studies, case–control studies, cross-sectional and other observational studies, systematic reviews, meta-analyses, narrative reviews, clinical practice guidelines, and consensus statements addressing…
核心结论
Bacterial β-glucuronidases can deconjugate estrogen glucuronides in the intestine, facilitating reabsorption and potentially influencing systemic estrogen availability [11].；Representative search terms included combinations of “menopause”, “postmenopause”, “gut microbiome”, “gut microbiota”, “estrobolome”, “estrogen metabolism”, “β-glucuronidase”, “short-chain fatty acids”, “trimethylamine N-oxide”, “bile acids”, “lipopolysaccharide”, “gut–brain axis”, “gut–muscle axis”, “metabolic syndrome”, “cardiovascular disease”, “metabolic dysfunction-associated steatotic liver disease”, “sarcopenia”, “precision nutrition”, “probiotics”, “synbiotics”, “phytoestrogens”, “hormone replacement therapy”, “metagenomics”, “metabolomics”, and “machine learning”.；Importantly, menopause-associated differences included changes in microbial functional pathways and lower abundance of microbial β-glucuronidase… ‖ 结论：Establishing whether this framework can translate into effective precision nutrition, pharmacomicrobiomics, or microbiome-informed interventions remains an important direction for future research.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★★★ 菌群是可远程部署、成本最低的干预变量，但因果性与个体化响应仍是主要瓶颈。命中核心 微生物组；最大样本量约 2,300；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 91,909 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：The Gut Microbiome-Estrogen Axis in Menopause: Implications for Body Composition, Cardiometabolic Health and Nutrition.
- 期刊与标识：Nutrients · PMID 42942900 · DOI 10.3390/nu18203330**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。