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The mean age of the cohort was 69.54 years (SD = 8.66); 61.9% were female, and 56.6% were APOE ε4 carriers. ‖ 结论：The study protocol was reviewed and a…

Of these, 36% (9/25) were observational studies (incorporating both cross-sectional and longitudinal designs), while the remaining 64% were experiment…

Both attenuated after adjustment for age, sex and education, and only the Digit Span Backward association remained nominally significant (β = −0.11, p…

Parallel-process latent growth curve models examined level and change associations; additional analyses evaluated hearing-aid moderation, Mendelian ra…

Male rats were treated with low-dose sildenafil from 12 to 18 months of age, with age-matched untreated rats serving as controls and young adult rats …

A single prospective cohort, the Osteoporotic Fractures in Men Study [22], contributed 53% of all participants, and the two largest studies [21,22] to…

Particular emphasis is placed on sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) across the heart, liver, adipose tissue, skeletal muscle and pancreatic β-cel…

Frailty prevalence was lower in the energy-sufficient group (6.1%) than in the energy-insufficient group (9.5%, p = 0.006).；Overall AMDR adherence did…

Changes in expression levels of senescent markers Senescence-associated β-galactosidase (SA-β-gal) is widely recognized as a prevalent indicator of ce…

Melatonin, a pleiotropic neuroprotective molecule with antioxidant, anti-inflammatory, and anti-apoptotic properties, has emerged as a promising candi…

The aim of this study was to perform a quantitative ultrastructural assessment of the mitochondrial apparatus of rat hepatocytes during aging under co…

For BTBR mice, the two-way ANOVA interaction for time spent in chambers was significant (F (2, 69) = 3.3, p = 0.04). ‖ 结论：For the reduction of restric…

All values are presented as mean ± SEM (n = 3). *P < 0.05, P < 0.01, *P < 0.001, **P < 0.0001. ‖ 结论**：In conclusion, this study demonstrates that comb…

At a constant chopper speed of 1400 rpm, extending the wet massing time from 3 to 7 min prompted a progressive and significant reduction in the compre…

At week 1, final body weight did not differ significantly between D1 and C1 (p = 0.710), whereas final fasting blood glucose was higher in D1 than in …

GLP-1RA-induced weight loss is associated with 25–39% of total lost mass being lean tissue [10], as suggested by data published in several clinical tr…

Each data point represents an individual mouse (n = 3 per group). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ns, not significant. ‖ 结论：These findings challe…

Over the entire experimental period, the overall laying rate in the MSB group (76.25±2.6%) was signifi- cantly higher than that in the CON group (65.5…

The typical pathological changes in AD include amyloid plaques formed by the deposition of β-amyloid (Aβ) (Glenner and Wong, 1984; Masters et al., 198…

Here we show that NgBR is highly expressed in microglia, where its deficiency drives progressive PD-like motor deficits and dopaminergic neurodegenera…

Introduction AD is the most common cause of dementia, accounting for approximately 60–70% of all cases worldwide.；It is estimated that around 10% of i…

Introduction Alzheimer’s disease (AD) is a complex neurodegenerative disorder in which amyloid-β (Aβ) deposition, abnormal tau phosphorylation, neuroi…

Multifactorial Mechanisms of Skeletal Muscle Dysfunction in COPD Not all COPD patients develop skeletal muscle dysfunction; approximately 40% show sig…

This combined approach revealed that extracellular amyloid-β (Aβ) plaques induce highly localized pre-synaptic toxicity and dystrophic neurites strict…

Initially, a comprehensive domain-wide search was performed using the following query string: (“Alzheimer disease” OR “AD”) AND (“amyloid β-protein” O…

(C) Volcano plot of DEGs between PAH and Controls (|log2FC| > 0.5, adjusted P < 0.05). ‖ 结论：Our findings suggest that a senescence-associated transcri…

In stage 1, sham-operated (SO), OVX, and OVX + MOX rats were evaluated by micro-computed tomography (micro-CT) to assess bone mass and by Alizarin Red…

These results identified a set of gut-serum synchronized metabolites associated with metformin-mediated improvement of lung inflammation, without esta…

Organ age gap (OAG) was defined as predicted age minus chronological age.；Predicted and chronological age were strongly correlated across organs (aver…

No meta-analysis, formal risk-of-bias assessment, or certainty-of-evidence grading was undertaken.；The nonrandom allocation and 25% overall attrition …