数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Neurodegenerative diseases (NDs) are a heterogeneous group of complex multifactorial disorders affecting millions of people worldwide [1].
方法
We searched publicly available scientific literature repositories, focusing on review articles published over the last 10 years and original research articles published primarily within the last 5 years.；Notably, a systematic review encompassing forty studies of urinary metabolomics in PD highlighted the potential of this approach to capture disease-associated metabolic alterations [105].；Of all the models discussed in this review, large mammals offer the highest overall translational potential across the three dimensions described above.；In this study, characterization of founder and F1knock-in pigs revealed consistent movement and behavioral abnormalities, and germline-transmissible early death.
核心结论
This combined approach revealed that extracellular amyloid-β (Aβ) plaques induce highly localized pre-synaptic toxicity and dystrophic neurites strictly restricted to the immediate plaque microenvironment, rather than causing widespread degeneration.；Furthermore, neuroscience research systematically underrepresents female donors, with female-derived lines comprising less than 30% of ND modeling cohorts.；By applying single-cell multi-omics to complex assembloids, researchers can detect non-cell-autonomous alterations within a healthy recipient organoid, driven exclusively by its physical coupling to a genetically altered or patient-derived donor culture [91]. ‖ 结论：In this context, a particularly promising direction for NDs research lies in strengthening the bidirectional connection between computational modeling and bedside clinical practice, ultimately facilitating the translation of mechanistic knowledge into more individualized therapeutic strategies.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 100,000；设计 系统综述、单细胞。
全文来源
PMC JATS 全文（正文 89,456 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Modeling Strategies for Neurodegenerative Diseases: In Vitro, In Vivo and In Silico Frameworks.
- 期刊与标识：Biomedicines · PMID 42940033 · DOI 10.3390/biomedicines14102227**
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