数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Senile osteoporosis (SOP) is an age-related metabolic bone disease characterized by reduced bone quality and increased fracture risk, closely associated with immune senescence.
方法
Effect of TNF-alpha inhibitor treatment on bone mineral density in patients with ankylosing spondylitis: a systematic review and meta-analysis.
核心结论
Changes in expression levels of senescent markers Senescence-associated β-galactosidase (SA-β-gal) is widely recognized as a prevalent indicator of cellular senescence [28, 29].；In the context of macrophage senes- cence, there is a notable elevation in SA-β-gal activ- ity, leading to its detectable accumulation within the cell through staining techniques.；These features may include SA-β-gal positivity, increased p16, p21, p53 or γH2AX expression, persistent DNA dam- age response, SASP production, telomere dysfunction, metabolic impairment, and/or stable cell-cycle arrest.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★☆☆ 细胞衰老清除/重编程是项目干预管线的核心支柱之一。命中核心 细胞衰老；设计 单细胞、多组学。
全文来源
BMC OA PDF（正文 83,237 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives.
- 期刊与标识：Immun Ageing · PMID 42947217 · DOI 10.1186/s12979-026-00586-4**
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