数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Hearing loss and loneliness are potentially modifiable risk factors for cognitive decline and dementia, but it remains unclear whether loneliness represents a causal pathway linking hearing loss to cognitive aging or whether these associations reflect shared vulnerability.
方法
We combined up to 18 years of data from the Survey of Health, Ageing and Retirement in Europe (SHARE; N = 10,375) with summary statistics from eight primary genome-wide association study sources and an independent neuroticism dataset used in sensitivity analyses.
核心结论
Parallel-process latent growth curve models examined level and change associations; additional analyses evaluated hearing-aid moderation, Mendelian randomization, multivariable Mendelian randomization, and colocalization.；At Wave 7, poorer hearing, greater loneliness, and poorer word-recall performance were associated, with a significant indirect association through loneliness.；Evidence for coordinated longitudinal mediation was limited, and the primary change-to-change indirect effect was not significant.；Current, but not cumulative, hearing-aid use was associated with a weaker concurrent hearing-loneliness association. ‖ 结论：The findings support late-life associations among hearing difficulty, loneliness, and cognitive performance but provide limited evidence that loneliness is a primary causal pathway linking hearing loss to cognitive aging.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★★★☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。顶刊证据。
原文题录
- 英文标题：Loneliness as a pathway linking hearing decline to cognitive aging: Longitudinal and genetic evidence.
- 期刊与标识：Alzheimers Dement · PMID 42949226 · DOI 10.1002/alz.71950**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。