数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
As people grow older, many begin to notice subtle changes in memory, attention or mental sharpness.
方法
Participants were recruited between March 2023 and June 2025 from the local community and all study procedures took place at the RoNeuro Institute for Neurological Research and Diagnostic, Cluj Napoca, Romania.；Eligible participants were men and women aged 50–75 years who reported SCCs but did not show evidence of clinically significant cognitive impairment (Montreal Cognitive Assessment score >25).；Eligibility additionally required a body weight of at least 50 kg for men and 45 kg for women and a body mass index between 18.0 and 29.9 kg/m2; consequently, no participant in this sample met criteria for obesity.；Subjective cognitive complaints were ascertained at screening through a face-to-face semi-structured clinical interview conducted by a clinician with each participant.
核心结论
Both attenuated after adjustment for age, sex and education, and only the Digit Span Backward association remained nominally significant (β = −0.11, p = 0.046).；A more positive mood, as measured by the Brief Mood Introspection Scale, was associated with better performance on the Digit Span Backward task at the uncorrected threshold (ρ = 0.15, p = 0.012).；This association did not survive correction for multiple comparisons (q = 0.062) and was further attenuated after adjustment (β = 0.09, p = 0.087). ‖ 结论：These findings suggest that, in individuals already reporting cognitive complaints, educational attainment, used here as a proxy of cognitive reserve, showed stronger associations with measured performance than current lifestyle variables did.
局限
Future work in this cohort should examine sleep using objective measures and longitudinal outcomes.；Possible explanations include the coarse four-level self-report measure used here, the cross-sectional design and the relatively restricted range of activity in this sample.；A further limitation concerns the scope of the cognitive assessment.
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 276；设计 Meta 分析、横断面。
全文来源
PMC JATS 全文（正文 35,714 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Lifestyle, Psychosocial and Demographic Correlates of Objective Cognitive Performance in Middle-Aged and Older Adults with Subjective Cognitive Complaints: A Cross-Sectional Baseline Analysis of the N-HANCE Cohort.
- 期刊与标识：Brain Sci · PMID 42939286 · DOI 10.3390/brainsci16101033**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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