数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Interestingly, although phytosterols themselves are efficiently excluded from host tissues, several microbiota-derived lipids have recently been reported to accumulate in mammalian tissues in an age-dependent manner, highlighting the potential for microbial lipid metabolites to enter and persist within the host.21 However, the distribution of phytosterol sulfates and the contribution of microbiota to host sterol…
方法
SIS, CAS, and STS detection in the human plasma further supports the translational relevance of these observations. which is generally considered poorly absorbed and efficiently excreted by the host, can be converted into its sulfated form in a gut microbiota-dependent manner.；Further studies will be required to clarify the physiological relevance of this pathway in vivo using a gnotobiotic system colonized with sult-knockout or wild-type bacterial strains and fed phytosterols. esources or reagents should be directed to and will be fulfilled by the lead contact, Makoto Arita ( marita@keio.jp ). available upon request. ble in MB-POST.
核心结论
Each data point represents an individual mouse (n = 3 per group). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ns, not significant. ‖ 结论：These findings challenge the prevailing view that phytosterols are biologically inert dietary components, revealing a previously unrecognized route by which gut microbes transform dietary sterols into metabolites that persist within the host.
局限
The precise physiological role of sterol sulfation in bacteria thus remains an open and important question that warrants further investigation.
对本项目的价值
★★★☆☆ 菌群是可远程部署、成本最低的干预变量，但因果性与个体化响应仍是主要瓶颈。命中核心 微生物组；队列：FHS；最大样本量约 3。
全文来源
PMC JATS 全文（正文 43,559 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Microbiome-dependent phytosterol sulfates production and tissue distribution in mice.
- 期刊与标识：iScience · PMID 42935490 · DOI 10.1016/j.isci.2026.117883**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。