数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Diabetes mellitus (DM) remains a rapidly escalating global health challenge with profound clinical and socioeconomic implications.
方法
This study was conducted at the Dicle University Health Sciences Application and Research Center following approval from the Dicle University Animal Ethics Committee (Decision No: E-35582840-020-494517, Date: 15 May 2023).；All procedures were performed in accordance with the “Guide for the Care and Use of Laboratory Animals” and international ethical guidelines.；Animals and Environmental Condition] Sixty-three adult male Wistar Albino rats (age: 8–10 weeks; weight range: 300–490 g, selected to ensure physiological maturity for long-term progressive metabolic tracking) were obtained from the Prof.；The animals were housed in a controlled environment with a temperature of 22 ± 2 °C, 65% ± 5% humidity, and a 12-h light/dark cycle.
核心结论
At week 1, final body weight did not differ significantly between D1 and C1 (p = 0.710), whereas final fasting blood glucose was higher in D1 than in C1 (p = 0.0023).；At week 8, overall differences among D4, C4, and T were significant for final body weight (Kruskal–Wallis p = 0.0011) and final fasting blood glucose (p = 0.0017).；D4 and T each differed from C4 for both outcomes (Holm-adjusted p = 0.0035), whereas D4 and T did not differ significantly from each other (final body weight, adjusted p = 0.132; final fasting blood glucose, adjusted p = 0.589). ‖ 结论：These findings indicate partial hepatic metabolic modulation by metformin despite persistent severe hyperglycemia.
局限
全文未设独立 limitations 节；结构上为非 RCT 设计，因果推断强度受限。
对本项目的价值
★★★☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。最大样本量约 7；设计 横断面。
全文来源
PMC JATS 全文（正文 19,750 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Effects of Metformin Treatment on Liver Glucose Metabolism-Related Enzyme Levels in Streptozotocin-Induced Diabetic Rats.
- 期刊与标识：J Clin Med · PMID 42941621 · DOI 10.3390/jcm15208108**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。