数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
The aim of this narrative review is to provide a synthesis of the interconnected roles of lysine acetylation, NAD+ metabolism and sirtuin activity in the regulation of cellular and mitochondrial metabolism in cardiometabolic disease.
方法
（全文无独立方法节，正文亦未给出可抽取的实验动作句）
核心结论
Particular emphasis is placed on sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) across the heart, liver, adipose tissue, skeletal muscle and pancreatic β-cells, with evidence from global and tissue-specific genetic models.；In pancreatic β-cells, impaired mitochondrial ATP production can disrupt glucose-stimulated insulin secretion (GSIS) [21,22,23].；Interest in sirtuins increased following early studies demonstrating that overexpression of Sir2 extended lifespan by 30% in Saccharomyces cerevisiae, highlighting the role of sirtuins in the regulation of longevity and aging [45]. ‖ 结论：Collectively, these findings position sirtuins and NAD+ metabolism as critical regulators of energy metabolism and key targets for therapeutic intervention in cardiometabolic disease.
局限
One major limitation is the incomplete understanding of the functional relevance of lysine acetylation sites.；Whether EV-based approaches can improve the delivery and efficacy of sirtuin-targeting therapeutics remains to be determined.；Future studies should therefore incorporate both sexes and determine whether sex influences sirtuin regulation and responses to sirtuin-targeting or NAD+-augmenting interventions.
对本项目的价值
★★★★☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。命中核心 NAD⁺轴；设计 多组学、问卷。
全文来源
PMC JATS 全文（正文 78,476 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Lysine Acetylation as a Regulatory Mechanism in Cardiometabolic Disease: A Focus on Sirtuins.
- 期刊与标识：Pharmaceuticals (Basel) · PMID 42943256 · DOI 10.3390/ph19101557**
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