最新收录 · 第 42 页
共 2198 篇，本页第 1231–1260 篇
Significant differences between treatment groups were observed for BMI (p < 0.001), fasting plasma glucose (p < 0.001), IRI (p < 0.001), HOMA-IR (p < …
线粒体呼吸链抑制导致 NADH 还原应激与 NADPH 耗竭并存；只纠正 NADH/NAD+ 无法挽救原代人成纤维细胞增殖，而扩大 NADP(H) 池可逆转增殖停滞与衰老特征。
结论：Therefore, the main translational question is not whether TCM-derived bioactive compounds can reduce inflammatory markers in experimental models, b…
Beyond antigen delivery, the CK5 scaffold acts as an intrinsic senomodulator associated with the downregulation of mitotic kinases Aurka/b and a conco…
(A) Relative abundance of the six most abundant genera (>5%) across the three clusters.；Letters above the boxes indicate significant pairwise differen…
How aging impacts neural tracking of speech and behavioral decrements in SIN perception remains unclear.；To address these questions, we measured neura…
More than half of the participants (53.42%, n = 86) had completed at least 12 years of education.；Notably, more than half of the participants (54.04%,…
We used stringent criteria (|log2 fold change| > 1 and adjusted p < 0.05) to detect differentially expressed genes (DEGs).
Formulations prepared with higher lecithin content (225 mg; N4–N6) were found to have significantly higher EE% (84.2–93.0%) than those with 150 mg of …
结论：The next generation of wound dressings and trials should therefore be state-aware, locally adaptive, and judged by durable restoration of tissue fu…
[35] found acalculia in 25 of 39 patients (64%), with poorer calculation associated with reduced left angular gyrus perfusion. ‖ 结论：Future studies usi…
Searches were conducted in PubMed, CINAHL, and Scopus.；Randomised controlled trials explicitly defining frailty were eligible.；Two reviewers independe…
Pairwise Meta-Analysis] For muscle mass, pooled results from nine studies showed that, compared to control, nutritional interventions significantly im…
Although ovarian tumor protease deubiquitinase 1 (OTUD1) participates in various biological processes, its specific functions in PD and its regulation…
However, persistent nutritional restraint could eventually become disadvantageous if nutritional and physiological reserves become insufficient as ind…
Building on the anticancer potential of oleuropein, a major olive tree (Olea europaea) metabolite, we evaluated a newly synthesised semi-synthetic ana…
Recent clinical studies have revealed that OL dysfunction and white matter changes occur at an early stage of Parkinson's disease (PD) and may be asso…
Three generations of epigenetic clocks (Horvath, Hannum, PhenoAge, GrimAge, DunedinPACE), transcriptomic markers of cellular senescence (p16INK4a, mTO…
Studies developing or validating oral frailty assessment instruments in older adults were included.；Clinical measures were summarized descriptively.；P…
In this cross-sectional study, 197 Japanese master athletes aged ≥ 35 years participated.；HRQoL was assessed using the Short Form-8, from which physic…
Significant heterogeneity was observed across the studies (P < .00001, I2 = 97%).；Similarly, significant heterogeneity was noted across these studies …
However, advances in the understanding of OA pathogenesis have led to the emergence of therapeutic strategies targeting metabolic dysfunction, inflamm…
衰老小鼠脑内 8-oxoGTP 累积；单独升高就足以造成突触功能障碍、tau 过度磷酸化、神经元丢失与认知下降，机制是它比 GTP 更强地激活 G 蛋白。
Moreover, support for several steps (MAC1/NOX2, HMGB1/TREM2, lipid peroxidation by-products, gut–brain signaling) comes from non-ozone or indirect mod…
Statistical significance levels are denoted as follows: *p < 0.05 and p < 0.01.；Biological n = 3. j Normalized VSV mRNA levels in BHK-21 cells transfe…
However, the mechanism by which NP promotes GN progression by inducing podocyte apoptosis remains unclear.；This study aimed to determine whether NP ex…
Despite the relatively low 26.46% overall amino acid sequence identity between LMD-3 and human NCOA7 [25], the func- tional domains and critical motif…
Much of this effect of PTPRD is likely to result from its role in modulating the neuronal activities of the key tau hyperphosphorylating kinases, glyc…
UVA accounts for approximately 95% of the solar UV that reaches the Earth’s surface and penetrates deeply into the reticular dermis.；In addition, paeo…
APOE ε4 carrier frequency increased across the clinical groups, from 30.7% in CN to 50.0% in MCI and 71.3% in AD dementia (p < 0.001).；Cognitive and f…