数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Cancer is a leading cause of death worldwide, driving continued research for innovative therapies with enhanced specificity and efficacy.
方法
Natural products have long been recognised as a valuable source of anticancer agents due to their structural diversity and unique biological activities.
核心结论
Building on the anticancer potential of oleuropein, a major olive tree (Olea europaea) metabolite, we evaluated a newly synthesised semi-synthetic analogue, GS32, for its cytotoxic activity in vitro.；Cytotoxicity assays revealed that GS32 exhibited broad-spectrum activity against various cancer cell lines, while also displaying differential toxicity between normal and cancerous cells.；Through transcriptomic analysis, we discovered that GS32 differentially disrupts key cellular pathways involved in stress response.；Importantly, targeted phosphoproteomic profiling uncovered context-dependent modulation of key signalling pathways, including the AKT/mTOR and NF-κB axes, as well as stress-response regulators. ‖ 结论：This study provides new mechanistic insight into the cellular effects of GS32 and identifies the compound as a candidate that merits further preclinical investigation.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★★☆☆ 营养感知与自噬轴决定"干预窗口 + 剂量方案"，是组合疗法的时间锚。
原文题录
- 英文标题：Cancer-selective cytotoxicity of a semi-synthetic derivative of oleuropein via proteostasis network impairment.
- 期刊与标识：Eur J Med Chem · PMID 42945875 · DOI 10.1016/j.ejmech.2026.119466**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。