数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Studies in older adults have shown reduced OP diversity, changes in community composition, and a loss of niche distinctness compared with younger individuals.7,11,12 These age-related shifts are discussed in relation to immunosenescence and chronic low-grade inflammation, and may contribute to the higher burden of respiratory infections in older adults.12,13,14 However, little is known about the upper-airway…
方法
Ultimately, this may help identify microbiome-immune patterns that can be used for early risk stratification and more effective preventive strategies in older adults. harynx (OP) samples of older individuals (ages 60 to 88), to describe the microbial composition, bacterial load, and cytokine patterns in a healthy state, and to determine the impact of a respiratory infection.；(C) Beta diversity based on Bray-Curtis dissimilarities, visualized by principal coordinates analysis (PCoA) (PERMANOVA, R2 = 0.41, p = 0.001). l microbiome during infection We analyzed the NP and OP microbiome composition of individuals with ILI in comparison with healthy controls.
核心结论
(A) Relative abundance of the six most abundant genera (>5%) across the three clusters.；Letters above the boxes indicate significant pairwise differences between clusters (Wilcoxon rank-sum test, adjusted p < 0.05). ‖ 结论：Together, these markers reflect coordinated activation of innate antiviral sensing pathways, epithelial interferon signaling, chemokine-driven immune cell recruitment, and downstream effector responses during respiratory infection.24,25,26 In contrast, only limited immune changes were observed in the OP niche, despite its anatomical connection with the NP.
局限
In addition, their response or resilience to infection is also very different, which should be considered in studies focused on respiratory tract infections.；Although we found clear evidence of site-specific immune and microbiome responses during acute influenza-like illness in older adults, certain limitations should be considered when interpreting our results.
对本项目的价值
★★★☆☆ 菌群是可远程部署、成本最低的干预变量，但因果性与个体化响应仍是主要瓶颈。命中核心 微生物组；最大样本量约 221。
全文来源
PMC JATS 全文（正文 49,245 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Linking nasopharyngeal and oropharyngeal microbiota to immune responses during influenza-like illness in an aging population.
- 期刊与标识：iScience · PMID 42935596 · DOI 10.1016/j.isci.2026.117929**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。