数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Chronic cutaneous wounds remain a global clinical problem because they combine tissue loss with persistent biological misclassification: the wound continues to behave as if acute danger is unresolved even after the original insult has passed.
方法
Because the article is not a systematic review, it does not make pooled effect estimates or grade clinical interventions.；Direct human wound and animal wound-healing studies were treated as the strongest anchors for disease relevance; single-cell, transcriptomic, biomaterial, and microbiome studies were used to assign cell states and translational readouts; mechanobiology, cancer-cell migration, senescence, and mitochondrial immunology studies were used only where they defined mechanisms that can be tested in wounded skin.；It is a narrative synthesis rather than a systematic review or meta-analysis; therefore, it prioritizes mechanistic coherence and hypothesis generation over pooled effect estimates.
核心结论
结论：The next generation of wound dressings and trials should therefore be state-aware, locally adaptive, and judged by durable restoration of tissue function.
局限
It is a narrative synthesis rather than a systematic review or meta-analysis; therefore, it prioritizes mechanistic coherence and hypothesis generation over pooled effect estimates.；Some elements of the proposed nuclear damage-response code are directly supported by wound studies, whereas others are extrapolated from mechanobiology, cancer-cell migration, mitochondrial immunology, senescence, and fibrosis models.；The framework should consequently be tested with cell-type-resolved human wound sampling, longitudinal biomarker validation, and intervention studies that distinguish transient repair-supportive stress signaling from persistent pathogenic activation.
对本项目的价值
★★★☆☆ 细胞衰老清除/重编程是项目干预管线的核心支柱之一。命中核心 细胞衰老；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 36,406 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：The Nuclear Damage-Response Code of Cutaneous Wound Repair: Mechanotransduction, cGAS-STING, Senescence, and Regenerative Interfaces.
- 期刊与标识：Biomolecules · PMID 42939680 · DOI 10.3390/biom16101427**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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