数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and hallmark neuropathological features, including β-amyloid (Aβ) plaque accumulation, hyperphosphorylated tau neurofibrillary tangles, oxidative stress, neuroinflammation, and synaptic dysfunction [1,2,3,4].
方法
（全文无独立方法节，正文亦未给出可抽取的实验动作句）
核心结论
Moreover, support for several steps (MAC1/NOX2, HMGB1/TREM2, lipid peroxidation by-products, gut–brain signaling) comes from non-ozone or indirect models (Section 2.2). ‖ 结论：We propose, as a working hypothesis, that these effects arise from a systemic oxidative–inflammatory signal that reaches the central nervous system, with sleep/circadian disruption and AD-related pathology as downstream outcomes that may reinforce each other.
局限
This discrepancy between a plausible mechanism and an inconsistent epidemiological signal may reflect several non-mutually exclusive factors: (i) exposure misclassification, since ambient ozone monitoring stations rarely capture individual indoor/outdoor exposure; (ii) confounding by co-pollutants, given that ozone rarely occurs in isolation from PM2.5 and NO2 in urban settings; (iii) differences in latency windows, as neurodegenerative outcomes may require decades of cumulative exposure while most cohorts have shorter follow-up; (iv) outcome heterogeneity, with some studies assessing clinical dementia and others subclinical biomarkers or sleep-specific endpoints; and (v) the possibility…
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。命中核心 线粒体；最大样本量约 395,651；设计 前瞻队列、观察性。
全文来源
PMC JATS 全文（正文 32,859 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Ozone as a Catalyst for Alzheimer's Disease and Sleep Disorders: Implications for Neurodegeneration Induced by Air Pollution.
- 期刊与标识：Biology (Basel) · PMID 42939505 · DOI 10.3390/biology15201904**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。