数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Atherosclerosis is the principal pathological substrate of ischemic heart disease, ischemic stroke, peripheral artery disease, and other major manifestations of cardiovascular disease.
方法
In this study, its effects were associated not only with a reduction in lesion area and improvement in the lipid profile, but also with sequential suppression of SREBP2, NLRP3, ASC, caspase-1, and IL-1β, both in vivo and in bone marrow-derived macrophages.；In this study, the formula reduced ROS, dampened NLRP3/caspase-1 signaling, and mitigated endothelial injury, accompanied by slower atherosclerosis progression in ApoE−/− mice.；Although the canonical ASC/caspase-1 axis was not fully validated in this study, it complements the overall logic well: in the aging vessel, impaired autophagy renders the macrophage more prone to inflammasome activation, and compounds capable of normalizing this layer of regulation may therefore reduce IL-1β availability as well.；Translational Limitations and Geroscience Perspectives Although the evidence summarized in this review supports a link between atherosclerotic inflammation and the NLRP3/caspase-1/IL-1β axis, the translational value of TCM-derived compounds and formulas remains limited at present.
核心结论
结论：Therefore, the main translational question is not whether TCM-derived bioactive compounds can reduce inflammatory markers in experimental models, but whether they can reproducibly modify the age-associated inflammatory mechanisms that contribute to plaque progression and instability.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★☆☆ 炎症衰老是几乎所有慢性老年病的公共通路，也是最有希望做"抗炎但保留免疫"解耦的靶点。命中核心 线粒体。
全文来源
PMC JATS 全文（正文 31,439 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Modulating the NLRP3/IL-1β Axis in Age-Related Atherosclerosis: Natural Products, Molecular Mechanisms, and Translational Perspectives-A Narrative Review.
- 期刊与标识：Biomolecules · PMID 42939664 · DOI 10.3390/biom16101409**
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