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Under identical conditions, the reference inhibitor roflumilast (0.1 nM) reduced activity to 43.2 ± 6.5%.；Survival rates at 168 hpf exceeded 95% in al…

A systematic review of clinical studies demonstrates that a significant proportion of patients with partial edentia remain without prosthetic replacem…

Hindlimb-supported standing time was significantly reduced in aged mice (3.75 ± 0.25 s, N = 4) compared with young mice (10.8 ± 2.35 s, N = 5; p = 0.0…

Regression lines and 95% CI (shaded areas) are presented for binarized groups defined by pPRS < 25th percentile (blue, “Low pPRS”) and > 75th percenti…

This review examines hypotheses of the pathogenesis of AD, including the involvement of amyloid-β peptide and hyperphosphorylated tau protein fragment…

Medications play a key role in the prevention and management of age-related CVDs, among which an important place is occupied by peptides, a special cl…

In a seminal experimental study, AChE was shown to accelerate the assembly of amyloid-β (Aβ) peptides into fibrils, whereas this effect was reduced by…

Approximately 35% of the encapsulated protein was released within the first hour, followed by cumulative release values of approximately 61%, 83%, and…

In an earlier issue of JGP, Hariharan et al.；(https://doi.org/10.1085/jgp.202614014) significantly add to our understanding of this pathology by showi…

In particular, a novel topical formulation containing niacinamide, arbutin, tranexamic acid, ubiquinone, a DHEA-like component, curcuma extract, and m…

PVS were automatically quantified in basal ganglia, centrum semiovale, hippocampus, and midbrain on 3T MRI.；Counts were modelled using Poisson or nega…

NHANES 13,379 名中老年人，四项指标（AL、HD、PhenoAgeAccel、KDM Accel）一致显示中等活动量的效应最优；高活动量在主要模型中均无显著关联，且跨年龄组与 KDM Accel 呈一致正相关。

Each point represents an individual biomarker effect estimate (beta) and error bars represent the corresponding 95% confidence intervals (CIs).；Adjust…

Primary analyses focused on relationships between plasma β-synuclein and synaptic density, and associations with related plasma biomarkers (tau phosph…

结论：These include the early detection of individuals at risk, identification of AD onset in patients with subjective cognitive impairment or mild cogni…

UK Biobank 38,577 名基线无衰弱者，中位随访 9.37 年、1,024 例新发衰弱；DHA 每五分位间距 HR 0.82（95%CI 0.69–0.97），而非 DHA 的 n-3 与总 n-3 均不显著。

Overall, the mean age was 56.48 years, 46.0% of participants were male, 95.9% were White, and 90.8% resided in England.；Among the 2,297 participants w…

Within the U.S., approximately 13–15% of children aged 2–5 years have obesity [93] and about 23% of adolescents aged 12–19 years are affected [94].；In…

The mean planning latency in patients with fibromyalgia (11,985 (915) ms) was not significantly different from that in the control group (10,424 (671)…

In South America, Brazil was consistently classified in low–low clusters for AHEI, with a median local Moran’s I of 0.92 (95% UI 0.56–1.17).；In East A…

80.8 ± 7.4 years, p < 0.001) and had a higher burden of age-related comorbidities.；11.9%), chronic obstructive pulmonary disease (19.0% vs.；9.2%) were…

In mammalian cells, endogenous H2S is primarily synthesized by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and the coupled cysteine a…

Recent analyses suggest that approximately 25–30% of tissue-enriched proteins, including those derived from skeletal muscle, can be detected in plasma…

The proteostasis network is a fundamental functional unit in biology with relevance to many diseases.；Despite its importance, the human proteostasis n…

Mitochondria are the principal sites of ATP production in cells, supplying over 90% of cellular energy requirements (21).；This intervention restores A…

Here we test the mechanistic role of ROR2 in RVF pathogenesis.；ROR2 was overexpressed or knocked down in neonatal rat ventricular myocytes and then ch…

1,240 名社区成年人、10 年随访（120 例死亡）：全脑脑龄 HR 1.044/年，而三脑区模型 C-index 0.81 对 0.79；血浆蛋白组把机制指向补体激活与适应性免疫失调。

Young (3-4 months) and aged (12-14 months) mice were intracerebrally (i.c.) injected with amyloid-β (Aβ1 - 42) to develop an AD-like phenotype and tre…

A CGA was performed, supplemented with age-related resilience scales.；The analysis of the interrelationships between the levels of age-related resilie…

Once the iPSC cultures reached 60–80% confluence, the iPSC maintenance medium, StemMACS XF (Miltenyi Biotec, Auburn, CA, USA), was replaced with Neuro…