数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Ageing is a universal yet heterogeneous process, driven by the accumulation of molecular and cellular damage that leads to functional decline, frailty, increased disease susceptibility, and ultimately death [1].
方法
Retained muscle-associated features in this study included FLNC, MYBPH, SSPN, OXCT1, HSPB1, BCL2L13, FHL3 and MUSTN1, linking the muscle signature to structural integrity, metabolism and stress-response pathways [59].；A systematic review of human proteomic ageing studies identified skeletal muscle vastus lateralis as one of the most informative non-blood tissues, reporting 916 age-associated proteins, while earlier smaller muscle studies reported more limited age-associated protein sets [25, 29].
核心结论
Recent analyses suggest that approximately 25–30% of tissue-enriched proteins, including those derived from skeletal muscle, can be detected in plasma [55].；In a multi-compartment ageing analysis, skeletal-muscle age-acceleration scores were associated with usual-pace walking speed (Spearman r = 0.35, p = 0.016), providing initial evidence that muscle proteomic ageing signatures relate to physical function [58].；ProtAge was associated with incidence of 18 major chronic diseases, multimorbidity and all-cause mortality, with each decile increase in proteomic age gap associated with an approximately 1.9-fold higher mortality risk [21]. ‖ 结论：Achieving this integration will require improved standardisation across proteomic platforms, development of longitudinal reference datasets, and clear regulatory frameworks defining how biological-age measures should be applied in clinical and preventive medicine.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★☆☆ 生物学年龄读数是选择替代终点的主要候选，直接影响终点设计与样本量估算。命中核心 表观时钟；最大样本量约 51,408；设计 系统综述、横断面。
全文来源
PMC JATS 全文（正文 53,445 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Proteomic ageing clocks: methods, mechanisms and the muscle connection.
- 期刊与标识：Genome Biol · PMID 42934806 · DOI 10.1186/s13059-026-04220-w**
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