数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Second, existing analyses have typically focused on narrow sets of outcomes, and the broader health relevance and consistency of diet-epigenetic aging associations across aging-related phenotypes remain unclear.
方法
For prospective analyses, vital status and cause of death are ascertained through linkage to the National Death Index via the NCHS Linked Mortality Files, enabling long-term mortality follow-up.；It was initiated in 2002 with an original sample of 11,391 participants aged 50 to 100 years and has been followed up biennially58.；The UK Biobank is a prospective cohort study of ~500,000 adults aged 40 to 69 years recruited in the United Kingdom in 2006–201059.；At baseline, participants completed extensive touchscreen questionnaires and interviews, underwent physical measurements, and provided biological samples.
核心结论
The current analyses included 7398 participants from the US Health and Retirement Study (HRS, mean age of 68.7 years, SD 11.0; 41% male) as the development cohort, and 23,830 from US NHANES as the external validation cohort (mean age of 62.7 years, SD 11.2; 48% male).；Two UK-based cohorts were further included to explore the health outcome implications, including 4895 from the English Longitudinal Study of Ageing (ELSA, mean age of 68.0 years, SD 7.9; 45% male), and 187,035 from the UK Biobank (mean age of 56.1 years, SD 8.0; 45% male).；The standardized GrimAge2Accel differences comparing the 90th with the 10th percentile of intake were 0.126 (95% CI 0.040, 0.212) for processed meat, 0.076 (95% CI 0.015, 0.138) for sugar-sweetened beverages, 0.075 (95% CI 0.015, 0.134) for fries, 0.070 (95% CI 0.037, 0.104) for beer, 0.069 (95% CI 0.011, 0.126) for artificially sweetened beverages,… ‖ 结论：Collectively, these findings support a close association between diet and biological aging and identify a dietary pattern that may be useful for studying diet in relation to epigenetic aging and healthy longevity.
局限
Omics and imaging-based integrative analyses provide preliminary clues to pathways that may link EDISEA to healthier aging.；This study has several limitations that warrant consideration.；The broadly comparable associations with health outcomes across cohorts support some degree of reproducibility across the populations investigated, although future studies are needed to provide more evidence for its applicability among other populations.
对本项目的价值
★★★★★ 生物学年龄读数是选择替代终点的主要候选，直接影响终点设计与样本量估算。顶刊证据；队列：UK Biobank、HRS、NHANES；最大样本量约 500,000；设计 Meta 分析、前瞻队列。
全文来源
PMC JATS 全文（正文 74,815 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：An epigenetic aging-informed dietary pattern is associated with a spectrum of aging-related health outcomes.
- 期刊与标识：Nat Commun · PMID 42934232 · DOI 10.1038/s41467-026-77790-9**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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