数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Periocular ageing affects the skin, eyelids, ocular adnexa, and underlying facial support.
方法
Preference was given to systematic reviews, randomized controlled trials, prospective cohort studies, consensus statements, and clinically relevant recent publications.；Case reports, retrospective series, and expert opinions were included only when higher-level evidence was unavailable or when discussing uncommon complications or emerging therapeutic approaches.；Evidence was appraised qualitatively according to study design, methodological quality, consistency, objective vs. subjective outcomes, duration of follow-up, periocular specificity, and clinical relevance.；Functional disease, active infection or inflammation, uncontrolled systemic disease, and unrealistic expectations should be addressed before elective intervention.
核心结论
In particular, a novel topical formulation containing niacinamide, arbutin, tranexamic acid, ubiquinone, a DHEA-like component, curcuma extract, and marine exopolysaccharides demonstrated substantial efficacy, achieving an average reduction of nearly 48% in under-eye hyperpigmentation after six weeks of twice-daily application without reported adverse effects.；Studies report over 40% improvement in pigmented dark circles with this modality (65).；Deep phenol–croton oil peels have demonstrated substantial and durable clinical improvement, with most patients achieving greater than 50% reduction in pigmentation and sustained benefits lasting up to several years, while maintaining a low complication rate (55). ‖ 结论：Its ophthalmology-oriented approach emphasizes when aesthetic findings overlap with ocular disease, when functional testing or referral is required, and how the strength and source of evidence should qualify technical recommendations.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★☆☆ 干细胞衰竭与部分重编程决定 rejuvenation 路线的可行边界与安全上限。命中核心 干细胞；设计 系统综述、前瞻队列。
全文来源
PMC JATS 全文（正文 44,052 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Periocular rejuvenation: current concepts and evidence-based management.
- 期刊与标识：Front Med (Lausanne) · PMID 42936325 · DOI 10.3389/fmed.2026.1943441**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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