数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
6 Recent research has focused on refining BBMs for use in primary care and point-of-care (PoC) diagnostics, aiming to improve accessibility and reduce diagnostic delays.7,8 This study aimed to explore the perspectives of diverse stakeholders, including patients, caregivers, healthcare professionals (HCPs), decision-makers, and AD biomarker researchers, on the potential role of BBMs in PoC in vitro diagnostic (IVD)…
方法
9 These comprised patients, to assess awareness and attitudes toward AD; caregivers, to understand challenges in care provision; HCPs from both primary and specialized care, to gather diagnostic and management perspectives; biomarker experts, to identify gaps in biomarker development; and decision-makers, to explore policy considerations at national and European levels.；This included 12 patients and 31 caregivers from AD association centers in Greece and Finland, 14 decision-makers, 29 healthcare professionals, of whom 8 were from primary care and 21 from specialized care, and 13 biomarker experts.
核心结论
结论：These include the early detection of individuals at risk, identification of AD onset in patients with subjective cognitive impairment or mild cognitive impairment, differential diagnosis, treatment selection, and monitoring of disease progression.7,14 The findings of this study reinforce the promise of BBMs as supportive biomarkers for AD as they are viewed favorably by HCPs and biomarker experts.
局限
Given the small sample size and limited statistical power, the findings should be considered exploratory.；A key limitation of this study is the limited geographic diversity of the sample, which was consisted mainly by Greek stakeholders across all groups.
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。设计 问卷。
全文来源
PMC JATS 全文（正文 10,231 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Perspectives on plasma biomarkers for point-of-care diagnostics in Alzheimer's disease: Insights into 2D-BioPAD.
- 期刊与标识：J Alzheimers Dis Rep · PMID 42948155 · DOI 10.1177/25424823261437790**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。