数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Norman and Shallice (1980) published a detailed model of high‐level cerebral information processing [1, 2].
方法
This was a cross‐sectional study of 53 adult subjects (age ≥ 18 years), comprising 27 patients who met the revised American College of Rheumatology criteria for fibromyalgia and 26 age‐ and sex‐matched healthy volunteers [14].；None of the participants were taking any medication or nutritional supplements known to be associated with changes in executive planning latency.；Each participant provided written informed consent.；[Executive Planning Latency] Executive planning latency was measured as the time interval between the presentation of the target arrangement and the first move in the one‐touch Stockings of Cambridge task in CANTAB (Cambridge Cognition, Cambridge, UK).
核心结论
The mean planning latency in patients with fibromyalgia (11,985 (915) ms) was not significantly different from that in the control group (10,424 (671) ms; p = 0.17).；The GLM was highly significant (χ 2 = 27.76, df = 5, p = 0.0001).；A significant positive correlation was observed between age and planning latency across the entire cohort (Spearman's r s = 0.394, p = 0.003). ‖ 结论：This study supports the hypothesis that frontal lobe executive function, as indexed by prefrontal cortical planning latency, is associated with serological evidence of exposure to the bacterial genera Borrelia, Ehrlichia/Anaplasma, Mycoplasma, and Chlamydia, as well as with age.
局限
Nevertheless, alternative explanations—including reverse causation (e.g., age‐related immune senescence increasing susceptibility to infection), unmeasured confounders, or artifactual associations arising from the small sample size—cannot be ruled out.；Therefore, the present results should be interpreted as preliminary evidence supporting further investigation, rather than as definitive proof of an infectious etiology for cognitive decline.
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 53。
全文来源
PMC JATS 全文（正文 22,835 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Prefrontal Planning Latency Associated With Age and Serological Evidence of Microbial Exposure.
- 期刊与标识：Chronic Dis Transl Med · PMID 42935792 · DOI 10.1002/cdt3.70074**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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