数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Malnutrition is highly prevalent among hospitalized older adults, with estimates suggesting that it affects up to 30% of individuals aged ≥65 years.
方法
CE INRCA 20031, 4 February 2021), which included participants selected from the Report-AGE project a large-scale observational study involving older adults hospitalized at the Italian National Institute of Health and Science on Aging (Istituto Nazionale di Riposo e Cura per Anziani, INRCA-IRCCS) (Trial Registration No.；Participants were eligible if they were 65 years of age or older, had been hospitalized for at least 24 h, and had provided written informed consent.；Patients with hematological malignancies or active COVID-19 infection were not considered eligible.；Individuals who died during hospitalization were excluded from the present analysis because the study focused on participants who completed the admission assessment and had available biological samples for the planned analyses.
核心结论
80.8 ± 7.4 years, p < 0.001) and had a higher burden of age-related comorbidities.；11.9%), chronic obstructive pulmonary disease (19.0% vs.；9.2%) were all more prevalent in the low-PNI group (p < 0.001). ‖ 结论：Longitudinal studies are needed to clarify the temporal relationships among these factors and to determine their clinical and biological significance.
局限
Because the analyses of LTL and inflammatory markers across BB-DNA tertiles were exploratory and based on nominal p-values, these findings should be considered hypothesis-generating.；These observations are consistent with previous studies linking malnutrition to cognitive impairment [63,64,65,66] and suggest that immunonutritional impairment may be associated with global cognitive vulnerability, while the domain-specific memory findings should be considered exploratory and interpreted with caution.；Although this exclusion was based on the availability of standardized assessments, it may have introduced some survivor or selection bias, since in-hospital mortality may be related to…
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 1,016；设计 横断面、观察性。
全文来源
PMC JATS 全文（正文 47,950 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Prognostic Nutritional Index, Circulating Bacterial and Viral DNA, and Neurocognitive Vulnerability in Geriatric Inpatients: A Cross-Sectional Study.
- 期刊与标识：Nutrients · PMID 42942958 · DOI 10.3390/nu18203387**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。