数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Aging is associated with a progressive loss of proteostasis and increased susceptibility to neurodegenerative and metabolic disorders.
方法
In this Review, we discuss the emerging role of protein persulfidation as a central regulator of proteostasis during aging and age-related disorders.；In this study, structural modeling further suggested that persulfidation induces subtle conformational changes that favor substrate binding and catalytic efficiency, providing a direct molecular mechanism by which H2S regulates metabolic enzyme activity.
核心结论
In mammalian cells, endogenous H2S is primarily synthesized by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and the coupled cysteine aminotransferase (CAT)/3-mercaptopyruvate sulfurtransferase (3-MST, MPST) pathway, although the relative contribution of each pathway varies among tissues and physiological conditions [10,11,12,13].；Approximately 40% of detected persulfidated proteins exhibited significant age-dependent changes, with the predominant trend corresponding to a global decline in persulfidation. ‖ 结论：In this review, we discuss emerging evidence linking loss of persulfidation to protein aggregation, biomolecular condensates, and age-related functional decline, and highlight therapeutic strategies aimed at restoring persulfidation as a promising avenue for healthy aging and disease intervention.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★★☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。命中核心 NAD⁺轴；设计 多组学。
全文来源
PMC JATS 全文（正文 53,118 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Targeting of Protein Persulfidation in Aging and Age-Related Disorders.
- 期刊与标识：Pharmaceutics · PMID 42942798 · DOI 10.3390/pharmaceutics18101266**
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